ObJECTIVE: Primary glomerular diseases or some systemic disorders such as diabetes (DM) may cause proteinuria. Irisin (IRI) is a hormone secreted as a response to physical exercise by the skeleton muscle and thought to be protective against many metabolic disorders such as DM, obesity. Decreased levels of irisin were observed in chronic kidney disease (CKD), type 2 DM and obesity. The aim of this study was to determine IRI levels in blood and saliva of proteinuric patients with and without diabetes. MATERIAL and METHODS:Sampling was from 15 diabetic, 15 non-diabetic proteinuria and 13 healthy control subjects. IRI concentrations were measured by using commercial ELISA kits. Statistical analysis was performed using SPSS 12. Groups were compared by the Kruskal-Wallis test and then Mann-Whitney post hoc test was performed. RESULTS:Plasma and saliva IRI levels of non-diabetic group were higher than the diabetic group. There was a significant positive correlation between plasma IRI concentrations and HDL, albumin levels but a negative correlation between plasma IRI and LDL levels.CONCLUSION: IRI levels were low both in plasma and saliva in diabetic subjects. IRI may be an important marker and/or therapeutic agent for disorders associated with energy expenditure and kidney diseases in the future.

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We report a 82-year-old women who presented with abdominal pain, nausea and multiple organ ischemia and infarction due to atrial fibrillation (AF). Her electrocardiography (ECG) was compatible with AF and the transaminase and creatinine levels and leukocyte counts were high. In addition to anticoagulation, supportive treatment was administered. After treatment her complaints decreased and the elevated laboratory parameters returned to nearly normal ranges. Abdominal symptoms of patients with atrial fibrillation should warn physicians regarding ischemia and infarction that may occur in abdominal organs.KEy wORDs: Spleen, Kidney, Infarction, Intestinal ischemia, Atrial fibrillation ÖZ Yazımızda, karın ağrısı, bulantı ile başvuran ve atriyal fibrilasyon (AF)'a bağlı çoklu organ iskemi ve enfarktı saptadığımız, 82 yaşındaki kadın olguyu sunmaktayız. Olgunun elektrokardiyografi (EKG)'si AF ile uyumlu, transaminaz, kreatinin seviyeleri ve lökosit sayısı ise yüksekti. Olguya antikoagülasyona ek olarak destek tedavisi uygulandı. Tedavi sonrası olgunun yakınmaları azalırken, yükselmiş olan laboratuvar parametreleri de neredeyse normal sınırlara geriledi. Atriyal fibrilasyonu olan hastaların karın ile ilgili semptomları, hekimleri karın içi organlardaki iskemi ve enfarkt olayları ile ilgili olarak uyarıcı olabilmektedir.