Neurofibromatosis (NF) type 1, also known as von Recklinghausen's disease, is an autosomal-dominant inherited disorder. Some tumors may develop in these patients, including optic pathway gliomas, astrocytomas, brainstem gliomas, chronic myeloid leukemia, and rhabdomyosarcoma. Patients with neurofibromatosis type 1 show also an increased risk of endocrine tumors, especially pheochromocytomas, whereas thyroid carcinoma is very rare. It is also rare for a neurofibroma to arise in the tissue neighboring the thyroid gland, and mimicking a nonfunctional thyroid nodule. This report presents a case of a neurofibroma adherent to the thyroid gland with thyroid papillary carcinoma in a 26-year-old woman with NF type 1.
Asinic cell carcinoma, previously known as 'acinic cell tumor'', is a neoplasm demostrating cytologic differentiation serous acinar cells. Differentiation sometimes only focally. This neoplasm does not show myoepitelial participation. The most frequent sites of occurence are the parotid gland. The most important prognostic indicators for acinic cell carcinoma are clinical stage and status of the resection margin. Frequent mitoses, high proliferative index (Ki67>%5), fokal necrosis, perineural invasion, gross invasion, desmoplasia, atypia and depletion of lymphocytes in the stroma have been associated with more frequent recurrens and metastases.
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