Porcupines are rodents, and their body is covered with hard bristles. Porcupines live in Asia, Africa, and Mediterranean countries, as well as in the Mediterranean and South East Anatolian regions of Turkey (1). Although there are many injuries reported in animals, only a small number of injuries have been reported for humans in the literature (2). Very few cases were found about human injury (3,4). In this paper we report two cases of porcupine quill injuries in humans. Case ReportsCase 1: A 17 year-old male patient was admitted to our emergency department after a porcupine attack. A quill pricked on his foot while he was walking on land (Figure 1). The quill was approximately in 3 cm deep at the dorsum of the foot in the physical examination. We removed the quill. Dressing and tetanus vaccine was performed. Cephalexin was prescribed orally 1 g twice/ day and the patient discharged. No complication occurred in the follow-up. Case 2: A 5 year-old girl was brought to the emergency department by her parents. While she was playing with a porcupine quill, it penetrated the periumblical area of her abdomen when she fell on it (Figure 2). Her general condition was moderate and she was conscious. Her blood pressure was 110/70 mmHg and pulse rate was 115/min. Hemogram and other biochemical parameters were in the normal range. Abdominal contrast Computed Tomography (CT) indicated that a foreign body penetrated the stomach. The patient underwent emergency surgery. The surgeon reported that the porcupine quill had penetrated the anterior and posterior gastric wall, and also caused a capsule defect on the second segment of liver (Figure 3). The defects were repaired successfully and a drain was left in the abdomen. The patient was treated with ampicillin intravenously (IV) 400 mg 49 ABSTRACT Introduction: Injury is a common reason for admission to the emergency department, but injuries which are caused by a part of a wild animal are extremely rare. Porcupinesare rodents that live in Asia, Africa, and Mediterranean countries, as well as inthe Mediterranean and South East Anatolian regionsof Turkey. Although there are many injuries reported in animals, only a small number of injuries have been reported for humans in the literature. Case Report: We report two cases of porcupine quill injuries. One case is a 17 year old boy and the other is a 5 year old girl. The quill was approximately in 3 cm deep at the dorsum of the foot in the physical examination of the boy. In the second case, while she was playing with porcupine quill, it penetrated the periumblical area of her abdomen when she fell on it. Conclusion: Porcupine quill spikes cause serious penetrating injury in areas where humans live and hunt. Therefore, porcupine arrows should be considered as cutting tools, and thus should be stored in a protected place. Porcupine arrows in a random environment may cause dangerous injury which is presented in our study.