Nearly half of the world's population is infected with Helicobacter pylori (H.pylori). A duodenal ulcer or stomach cancer can be caused by the infection by this bacterium. The aim of this work is to assess the levels of CD14 and CD163 in H.Pylori-positive patients infected with duodenal ulcer (DU) and gastric cancer (GC) and determine the prevalence of Helicobacter Pylori-oncogenic protein cytotoxin-associated gene A strains (H.pylori-CagA).  This study included 89 individuals distributed as follows: 20 healthy individuals as controls and 69 patients infected with H. Pylori have been divided as follows: 27 patients infected with H.pylori only (H.Pylori+), 22 H.pylori+DU and 20 H.pylori+GC. H. Pylori-oncogenic protein cytotoxin-associated gene A strains (H-pylori-CagA) were diagnosed based on a qualitative reverse-phase Enzyme Immunoassay Technique. CD163 and CD14 were measured in all individuals' serum using the Enzyme-Linked Immunoassay (ELISA) test.  Out of 69 patients infected with H.pylori, there was one CagA strain in H.pylori+; two and five strains were recorded in H.pylori+DU and H.pylori+GC, respectively. CD14 and CD163 serum concentrations were significantly higher (P≤0.05) in H. pylori+, H. pylori+DU and H. pylori+GC than in controls. Conclusions: Patients with CagA strains infection are at risk of developing a duodenal ulcer and stomach cancer.

Most people around the world are infected with Helicobacter pylori (H.pylori); it can lead to duodenal ulcer (DU) and gastric cancer (GC). The main objective of this study is to determine the correlation between CD14 and CD163 in individuals with DU and GC infected with H.pylori. Sixty nine individuals were included in this work; 27 patients infected with H.pylori only (H.Pylori+), 22 patients infected with H.pylori with DU and 20 patients infected with H.pylori with GC. CD14 and CD163 were measured in all individuals' serum using the Enzyme-Linked Immunoassay (ELISA) test. The results proved there was negative correlation between CD14 and CD163 in H.pylori-positive patients (y= -0.0263x+1.4179). While, there was positive correlation in H.pylori-positive patients with DU (y= 0.0932x+1.6647) and with GC (y= 0.0607x + 1.9824). In conclusion: CD14 and CD163 have a synergistic protected effect in H.pylori-positive patients with DU and GC.

A case-control study was carried out in Al- Sader Medical City in AL-Najaf Governorate, Iraq, during period from 1/9/2021 to 1/3/2022. Helicobacter pylori (H. pylori) Antigen Rapid Test Cassette (Feces) has been used to diagnosis all patients infected with H. pylori. All patients with duodenal ulcers and gastric cancer have been diagnosed by a physician using an endoscope and biopsy, respectively, in the department of tumors at AL-Sader Medical City. The results proved that there were 27 patients; 11 male (40.7%) and 16 female (59.3%) infected with H.pylori. Age group 20-30 was the highest infected with H.pylori (14 patients, 51.9%) followed by 31-40 (8 patients 29.6%), 41-50 (4 patients 14.8%) and 51-60 (1 patient 3.7%). Conclusions: Helicobacter Pylori may cause the most cases of duodenal ulcer and gastric cancer in patients that infected with this bacterium.