No abstract

No abstract

Neck and back pathologies cause considerable pain and suffering, and treatment costs tens of billions per year. A common source of problems is degeneration and herniation of the gel-like nucleus pulposus (NP) component of the intervertebral disc, and NP repair/replacement has been a long-term health care goal. We have investigated a novel class of hydrogel/foam composites to identify biocompatible materials with similar viscoelastic characteristics to the native tissue. Low acyl gellan gum (G) and agarose (A) in varying weight percentages were infused into Sugi® cellulose sponge material (F) to produce three candidate materials in addition to those samples without foam. Dynamic oscillatory shear tests and dynamic oscillatory axial compression test tests were conducted on the materials at frequencies between (f = 0.1-10 Hz) to measure elastic (storage) and viscous (loss) moduli in shear and compression conditions. The results show that hydrogel/foam composites show greater viscoelastic properties than hydrogel alone. Various materials of hydrogel and hydrogel/foam composite closely match the viscoelastic properties of native NP tissue.

We have developed a simple, inexpensive and innovative device for reproducing the global mechanical behavior of spinal motion segments and the local mechanical environment experienced by lumbar intervertebral discs. The device has several broad functions: (1) exploration of the basic mechanics underlying this complex skeletal system, (2) connecting changes in tissue characteristics with overall motion segment function, and (3) evaluation of strategies for repair and replacement of disc components. This “disc emulator” consists of three main parts: (1) an artificial annulus fibrosus (AAF), made out of silicone, with lumbar disc geometry and adjustable material properties, (2) a hydrogel nucleus pulposus (NP) also with lumbar disc geometry and adjustable material properties, and (3) simulated vertebral bodies 3D printed with trabecular bone simulated by a rigid polymer (Acrylonitrile Butadiene Styrene, ABS) and end plates crafted from a compliant polymer (Thermoplastic Polyurethane, TPU). Mechanical compression experiments have been conducted using the disc emulator under similar protocols to published studies of human cadaver samples. Bulging of the artificial annulus fibrosus was examined under axial compression loads using digital image correlation (DIC), and results show close agreement. We see this approach of using anatomical geometry and multiple adjustable components as a useful means of creating accurate local stress/strain environments for preliminary material evaluation, without the variability and difficulty inherent indirect testing of cadaveric materials.