BackgroundRecurrent pregnancy loss (RPL) or recurrent spontaneous abortion is an obstetric complication that affects couples at reproductive age. Previous reports documented a clear relationship between parents with chromosomal abnormalities and both recurrent miscarriages and infertility. However, limited data is available from the Arabian Peninsula which is known by higher rates of consanguineous marriages. The main goal of this study was to determine the prevalence of chromosomal abnormalities and thrombophilic polymorphisms, and to correlate them with RPL and consanguinity in Saudi Arabia.MethodsCytogenetic analysis of 171 consent patients with RPL was performed by the standard method of 72-h lymphocyte culture and GTG banding. Allelic polymorphisms of three thrombophilic genes (Factor V Leiden, Prothrombin A20210G, MTHFR C677T) were performed using PCR-RFLP (restriction fragment length polymorphism) and gel electrophoresis.ResultsData analysis revealed that 7.6 % of patients were carrier of numerical or structural chromosomal abnormalities. A high rate of translocations (46 %) was associated to increased incidence of RPL. A significant correlation between consanguineous RPL patients and chromosomal abnormalities (P < 0.05) was found. Both Factor V Leiden and Prothrombin A20210G allelic polymorphisms were significantly associated with a higher prevalence of RPL.ConclusionsThis study demonstrated a strong association between RPL and the prevalence of chromosomal abnormalities and inherited thrombophilia. Given the high rate of consanguineous marriages in the Saudi population, these results underline the importance of systematic cytogenetic investigation and genetic counseling preferably at the premarital stage or at least during early pregnancy phase through preimplantation genetic diagnosis (PGD).

Hydrocele with intraabdominal extension is a rare condition in children. We managed 10 hydrocele in 7 infants (3 bilateral and 4 unilateral). Eight hydrocele were abdominoscrotal and two were abdominoinguinal which represents intraabdominal extension of encysted hydrocele. Obstetric history of 6 mothers of this present study's patients supported the authors' previously proposed explanation of the push-up of the hydrocele intraabdominally by external pressure on the scrotoinguinal compartment, this pressure is created by strong uterine contractions or intra-uterine fetal position. In this paper, we present our experience in management of this condition including some of its important clinical and morphological features. Additionally, we propose to call this condition as "Hydrocele with intraabdominal extension" which includes abdominoscrotal and abdominoinguinal in males and the abdominoinguinal (pushed up hydrocele of canal of Nuck) in females.

No abstract

No abstract