Introduction: Pediatric urolithiasis remains endemic in low-resource countries affecting children <1 to 15 years. This study aimed to investigate the diagnosis and the treatment options of pediatric urolithiasis and compare that with the literature. Materials and methods: This study retrospectively evaluated patients who had been diagnosed with urolithiasis in the in department of pediatric emergency and reanimation and the department of pediatric surgery in Hedi Chaker hospital in Sfax between 2001 and 2016. Results: Over 16 years period, we diagnosed and managed 78 children with urolithiasis. 44 were male (56%) and 34 were female (44%). The median age was 54 months (4 to 144 months). Family history of urolithiasis was found in 23 patients (29.5%). The diagnosis of urolithiasis was made after Urinary tract infection in 23 (29.5%), abdominal pain in 16 (20.5%), Hematuria in 9 (11.5%), nephritic colic in 8 (10.5%), dysuria in 11(14%) and after antenatal diagnosis of malformative uropathies in 11 (14%) patients. The treatment were surgery in 32, medical in 30, LEC and endoscopy in 8 patients. The mean of follow up was 36 months and we had 11 recurrent urolithiasis. Conclusion: Pediatric urolithiasis remains a devastating health problem. Their management requires more exploration especially in the etiology research for a best management.

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The adverse renal effects of aminoglycosides are increasing, up to 20% in patients treated with this class of antibiotic, nephrotoxicity is manifested by the renal insufficiency with a variable degree, usually clinically silent but the return to the former state is not always obtained which progresses towards chronic kidney disease. After studying a declaration of an adverse case at the pharmacovigilance service of the UHE of Oran.The impact of nephrotoxicity of aminoglycosides in the aggravation of pre-existing renal insufficiency has been demonstrated according to the French and Anglo-Saxon method of accountability that is why information on pharmacological therapeutic monitoring of STP should be recommended. In conclusion, the knowledge of the factors favoring the nephrotoxicity of aminoglycosides, the respect of the dosages and the reduction of the duration of the treatment allows the practitioner to take measures in order to prevent and to reduce the frequency of the renal complications.The side effect of aminoglycoside therapy may occur in up to 20% of the exposed patients treated with this antibiotic class, this nephrotoxicity is manifested by varying degrees of renal insufficiency (IR), usually clinically silent but the return to the previous state is not always got, sometimes progress to chronic renal disease. Following the study of a case of adverse reaction reporting; has been shown by the French and Anglo-Saxon method of accountability, the impact of aminoglycosides' nephrotoxicity in the aggravation of existing IR, why therapeutic drug monitoring TDM actualities are recommended. In conclusion, knowledge of predisposing factors nephrotoxicity of aminoglycosides, respect the doses and reducing the duration of treatment allows the practitioner to take measures in order to prevent and decrease the frequency of renal complications.

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