We aimed to find the most useful biomarker by examining the prognostic effect of neutrophil‐lymphocyte ratio (NLR), lymphocyte‐monocyte ratio (LMR), platelet‐lymphocyte ratio (PLR), and lymphocyte‐C reactive protein ratio (LCR) in patients with coronavirus disease 2019 (COVID‐19). Three hundred and four patients diagnosed with COVID‐19 infection in our hospital within 5 months (April–August 2020) were examined. Laboratory values and demographic findings of the patients were analyzed retrospectively. Thirty‐six patients were diagnosed with severe cases. The ratio of NLR, LMR, PLR, and LCR of patients with severe and those with nonsevere clinical symptoms were statistically analyzed. The NLR and PLR ratios of those with severe clinical symptoms were significantly higher ( p < 0.001), the LCR rate was significantly lower ( p < 0.001), and there was no significant difference in the LMR rate ( p = 0.199). When we examined other peripheral blood parameters, we found that CRP was high, lymphocyte and monocyte were low ( p < 0.001), but neutrophil ( p = 0.416) and platelet ( p = 0.998) were not statistically different between the groups. According to the results, routine blood values are abnormal in patients with COVID‐19. NLR, PLR, and LCR ratios can be used as more significant biomarkers than other values in predicting the prognosis of patients.

AMAÇMaksillofasiyal kırığı bulunan hastalar, bu travmaya eşlik eden kafa travması geçirme konusunda yüksek risk altın-dadırlar. Bu hastalarda kafa travmasının erken anlaşılma-sı hastanın sağkalımı ve iyileşmesi için kritik öneme sahiptir. GEREÇ VE YÖNTEMOcak 2006 ile Eylül 2009 tarihleri arasında hastanemizin acil servisine maksillofasiyal kırık nedeniyle gönderilen 246 hastanın kayıtları geriye dönük olarak tarandı. Hastaların yaş, cinsiyet, maksillofasiyal travmanın nedeni, tipi, yerleşimi ve kafa travması analiz edildi. BULGULARHastaların yaşlarının ortalaması 23,61±16,75 idi (%83,3 erkek, %16,7 kadın). Kraniyal yaralanma maksillofasiyal travmalı 38 hastada gözlendi. Hastalar arasında tek yüz kemiği kırığı bulunanlarda kafa travması riski çoklu kırıklı hastalara göre 3,44 kat daha az gözlenirken (p<0,001), yüz kemiği çoklu kırılan hastalarda kafa travması geçirme riski anlamlı derecede artmıştı (p<0,001). İçinde nazal kemik, maksiller kemik, mandibular kemik ve frontal bölge kırığı bulunan hastalarda kafa travması riski önemli derecede artmıştı (p<0,05 her bir grupta). SONUÇÇoklu yüz kemik kırığı bulunan hastalarda klinik bulguları olmasa dahi kafa travması yönünden araştırılmaları gerekir.Anahtar Sözcükler: Maksillofasiyal travma; kafa travması; yüz kemik kırığı.

Trace elements are essential components of biological structures, but alternatively, they can be toxic at concentrations beyond those necessary for their biological functions. Changes in the concentration of essential trace elements and heavy metals may affect acute hemorrhagic stroke. The aim of this study was to measure serum levels of essential trace elements [iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), and magnesium (Mg)] and heavy metals [cobalt (Co), cadmium (Cd), and lead (Pb)] in patients with acute hemorrhagic stroke. Twenty-six patients with acute hemorrhagic stroke and 29 healthy controls were enrolled. Atomic absorption spectrophotometry (UNICAM-929) was used to measure serum Fe, Cu, Pb, Cd, Zn, Co, Mn and Mg concentrations. Serum Cd, Pb and Fe levels were significantly higher in patients with acute hemorrhagic stroke than controls (p < 0.001), while serum Cu, Zn, Mg and Mn levels were significantly lower (all p < 0.001). However, there was no significant difference between the groups with respect to serum Co levels (p > 0.05). We first demonstrate increased Cd, Pb, and Fe levels; and decreased Cu, Zn, Mg, and Mn levels in patients with acute hemorrhagic stroke. These findings may have diagnostic and prognostic value for acute hemorrhagic stroke. Further studies are required to elucidate the roles of trace elements and heavy metals in patients with acute hemorrhagic stroke.

IntroductionBoth hepatitis B virus (HBV) and hepatitis D virus (HDV) infection play an increasingly important role in liver diseases. The main objective of this study was to investigate the socio-epidemiological, laboratory and radiological aspects of both HBV and HDV infection near the Iranian border of Turkey.Material and methodsThe study included 3352 patients with HBV and HDV infection. Socioepidemiological, laboratory and radiological aspects of the study subjects were retrospectively examined. Comorbid metabolic diseases were not assessed due to the retrospective design of the study.ResultsMost of the study subjects were HBe antigen negative. No significant difference in terms of HBV-DNA levels or HBe antigen seropositivity was detected between the city centre and rural areas (p > 0.005). The mean HBV-DNA level in the anti-HDV-positive group was significantly lower than in the anti-HDV-negative group (p < 0.001). The rate of HDV-RNA positivity in women was higher than in their male counterparts (p = 0.017). Anti-HDV-IgG was detected in 18.4% of tested subjects who came from an urban area. In contrast, 12.5% of subjects of the rural group had a positive result for anti-HDV-IgG. Among 134 ultrasonographically evaluated delta hepatitis patients, 37.3% had liver cirrhosis. On the other hand, in 1244 patients with hepatitis B monoinfection, there were 90 patients with liver cirrhosis. Radiologically, the rate of hepatic steatosis in delta hepatitis patients was lower than in those with HBV monoinfection.ConclusionsHepatitis D virus infection was particularly prevalent among the urban population as well as in female subjects. More broadly, the current observations are the first to suggest an inverse correlation between delta hepatitis and ultrasonography-proven hepatic steatosis.

Findings from the study suggest an association between increased oxidative stress levels, decreased antioxidant levels and increased prolidase enzyme activity in patients with acute hemorrhagic stroke compared with controls. More studies are needed to elucidate mechanistic pathways on oxidative stress in patients with acute hemorrhagic stroke.