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10 A possible explanation of the role of ATP in the transformation of II to III is that it gives rise to additional phosphorylated products, which, however, are too rapidly converted to III to be detected.

As a result of the discovery that T2, T4, and T6 bacteriophages contained a new pyrimidine, 5-hydroxymethyl cytosine, not present in appreciable quantities in the host nucleic acids (Wyatt and Cohen, 1952), this laboratory began studies on the metabolic origin of this compound (Cohen, 1953). As one approach to this problem 1 This research was aided by a grant from the Commonwealth Fund.

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