Background: Enhanced recovery programs (ERPs) are evidence-based protocols designed to improve functional rehabilitation after surgery. They lead to improvement in patient outcomes while reducing length of hospital stay. Objective: This study aimed to compare surgical outcomes between women undergoing major gynecologic surgeries before and after implementation of enhanced recovery after surgery (ERAS) protocol. Patients and Methods: This erective observational study was carried out on patients attending to Zagazig University Hospitals for Elective Gynecological Oncologic Surgeries in the period between August 2018 and August 2019. Patients and methods: This study included 54 patients who were presenting for elective gynecological oncologic surgeries. They were classified into 2 groups. Group 1 include 27 patients who were exposed to the ERAS protocol regimen for the pre, intra and postoperative care. Group 2 include 27 patients who were exposed to the conventional care known in the literature. Clinical outcomes and compliance were obtained using the ERAS Interactive Audit System. Results: This study showed that the mean length of hospital stay was 38.29 ± 4.95 hours in group A and 68.44 ± 6.5 hours in group B with significant difference between the two groups. Postoperative complications rate was 7.4% in group A vs 11.1% in-group B with no significant difference between the two groups. Conclusions: Systematic implementation of ERAS gynecologic oncology guidelines across a healthcare system improves patient outcomes and saves resources.