The present research on the effect of chemical inducers of systemic acquired resistance in sweet potato (Ipomoea batatas Lam.) was developed during 2012-2013 at Cañete, Peru. The objective was to determine the effectiveness of some chemicals used for the induction of systemic resistance on agronomic performance of sweet potato in order to improve overall health in the fields, increase of plant survival and reduce the impact of agrochemical applications. Three sweet potato genotypes were sown in RCBD with 3 replications during in the winter of 2012 and summer of 2013. Additionally two chemical inducers of SAR, potassium phosphite (2.5 ml•L −1 ) and acetylsalicylic acid (100 mg•L −1 ) were applied plus untreated control plots. The results indicated that there were no statistical differences (p > 0.05) for root weight•plant −1 or survival percentage and there were statistical differences in weight of foliage•plant −1 for chemical treatments. Statistical differences were found between seasons and interaction of seasons and genotypes for foliage weight, suggesting a physiological effect by the application of inducing systemic resistance chemicals on the agronomic performance of sweet potato. It was concluded that specific effect of acetylsalicylic acid increased the weight of foliage•plant −1 in genotypes of sweet potato and there were no influences for root yield.