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Background. Interleukin-10 (IL-10) is a multifunctional cytokine has been seen to play a relevant role in the pathogenesis of sepsis. We examined the association between a single nucleotide polymorphism (SNP) in IL-10 -1082G/A in patients with sepsis in Cali city.Methods A total of 100 patients with sepsis and 50 control subjects were enrolled in this study. Blood samples were collected from all patients in EDTA containing tubes. IL-10-1082G/A gene promoter polymorphism was analyzed by Sequence Specific Polymerase Chain Reaction (SS-PCR), while levels of serum IL-10 were measured by Enzyme Linked Immunoassay Assay (ELISA) in patients with sepsis and healthy controls.Results. AA homozygous genotype was found more frequently in patients (32%), compared with controls (18%). AA homozygous patients showed had a increased risk of developing infection by Gram-negative bacteria (OR=2,875; 95% CI = 1.162-7.113; p = 0.020), and significantly high plasma levels of IL-10 (OR= 4.800, 95% CI 1.652–13.944; p=0.002). AA homozygous patients high plasma IL-10 levels have greater risk of developing sepsis (63.6%; OR = 4,894; 95% CI: 1,337-17,909; p = 0.002). In this group, Afro-Colombian individuals were overrepresented among the sepsis patients with high plasma IL-10 levels (OR=1.661; 95% CI: 1.408-1.959; p=0.036).Conclusion Our study concluded that AA genotype of IL-10 -1082G/A polymorphism is a risk factor for high IL-10 production and development of sepsis by Gram negative bacteria, especially, Afro-Colombian patients.

Objective:SARS-CoV-2 infection is spreading around the world, including countries from Latin america. The purpose of the study was to analyse the clinical characteristics of COVID-19 patients admitted to the San Jose de Popayan Hospital in Colombia. Methods:A retrospective study was conducted with 620 COVID-19 patients. The hospitalized patients were divided into two groups on admission, that is, nonsevere and severe. Results:The mean age was 53 years and a greater number of male patients developed the severe form (73.3%) and died (67.1%). The leading comorbiditieswere HTN, cardiovascular disorders, diabetes,Obesity, respiratory disorders, rheumatologic disease, chronic kidney disease, malignancyandmalnutririon. Malnutrition represented a greater risk in the population over 65 years of age (OR= 8.563, 95% CI: 2.290-32.029]; p value <0.001).On comparative analysis of both groups (nonsevere and severe), a significant increase in severity was determined in advanced age: 56-65 years (OR= 2.668; p<0.001) and >65 years (OR= 7.448; p<0.001), anosmia at hospital admission (OR= 4.599; p=0.004) and cough (OR= 1.867; p=0.002). Conclusions:Our study estimated thatage over 65 years with malnutrition and signs of cough and anosmia on admission were estimated as higher risk factors to develop severe disease.