Central Serous Chorioretinopathy (CSCR) is the detachment of the neurosensory retina and/or Retinal Pigment Epithelium (RPE) due to accumulation of fluid in the sub retinal space, mostly confined to the macula. Hereby, presenting a rare case of a 32-year-old patient with defective vision in both eyes, she was a known case of Chronic Kidney Disease (CKD) on haemodialysis. On examination best corrected visual acuity was 6/9, on dilated fundus examination with ring reflex in both eyes, Optical Coherence Tomography (OCT) macula showed detachment of the neurosensory retina from RPE with the sub retinal fluid. This case is considered to be rare due to the unusual association noted between CSCR and End State Renal Disease (ESRD), in a female patient with no history of usage of corticosteroids or known identifiable risk factors. Hence, it is essential to screen patients with ESRD for CSCR to prevent vision threatening complications.

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder. It has a relapsing and remitting course.1 It is found to be more common in Asian and African population. It is more common in females than males. Usual age of onset is between 15 years and 45 years.2 It occurs in one third of patients with SLE and is associated with morbidity. SLE can involve eyes, joints, brain, kidney, skin, serosa, ears, lung, and gastrointestinal tract. Manifestations in SLE occur due to recurrent vascular injury, which is secondary to immune complex deposition, thrombosis, leukothrombosis.3 Thrombotic complications are found to be more common in Caucasians.4 Ocular manifestations can be seen in one third of the population with SLE.1,5 Triggering factors such as exposure to sunlight, use of sulphonamides, pregnancy, infections, and contraception have been known to exacerbate the disease.2,6 Hallmarks of ophthalmic involvement in SLE include severe tear deficiency, retinal vasculopathy and scleral inflammation.3 Most common ocular presentation is keratoconjunctivitis sicca.7 Fundus examination in the eye is the only part of the body where the vasculature can be directly visualized and hence SLE retinopathy indicates the amount of systemic vascular damage, retinopathy indicates high disease activity in patients with SLE and hence indicates a poor survival of these patients.2 Most patients with SLE develop secondary Sjogren’s syndrome.

BACKGROUND Dry eye disease is one of the most common presentation in hospital with varied presenting complaints and which can lead to various complications. Study is done on 200 eyes diagnosed with dry eyes in a tertiary centre in South India using Schirmer; and tear break up time test. Their central corneal thickness is measured using specular microscopy. The correlation of dry eye disease and central corneal thickness is assessed. Dry eye disease diagnosed using Schirmer test showed a strong correlation with the central corneal thickness. A significant reduction in central corneal thickness was observed in dry eyes disease diagnosed with Schirmer disease. The factors affecting dryness includes inflammatory component and evaporating component. Based on my study the results of dry eyes due to inflammation of eye can be considered to have more association to the pathogenesis in relation to central corneal thickness. Inflammation decreases the eyes’ ability to produce normal tear. METHODS 200 eyes of 100 patients who presented in hospitals diagnosed with dry eye disease were included in the study. The central corneal thickness of these patients was measured and corelated with the degree of dryness using Shermer’s test and tear film break up time. RESULTS A statistical significance was observed between the inflammatory component causing dry eyes and the CCT values. CONCLUSIONS There is a significant association between the central corneal thickness and dry eye diseases. KEY WORDS Central Corneal Thickness, Schirmer’s Test, TBUT.