Summary SARS-CoV-2 Spike protein is critical for virus infection via engagement of ACE2 1 , and is a major antibody target. Here we report chronic SARS-CoV-2 with reduced sensitivity to neutralising antibodies in an immune suppressed individual treated with convalescent plasma, generating whole genome ultradeep sequences over 23 time points spanning 101 days. Little change was observed in the overall viral population structure following two courses of remdesivir over the first 57 days. However, following convalescent plasma therapy we observed large, dynamic virus population shifts, with the emergence of a dominant viral strain bearing D796H in S2 and ΔH69/ΔV70 in the S1 N-terminal domain NTD of the Spike protein. As passively transferred serum antibodies diminished, viruses with the escape genotype diminished in frequency, before returning during a final, unsuccessful course of convalescent plasma. In vitro , the Spike escape double mutant bearing ΔH69/ΔV70 and D796H conferred modestly decreased sensitivity to convalescent plasma, whilst maintaining infectivity similar to wild type. D796H appeared to be the main contributor to decreased susceptibility but incurred an infectivity defect. The ΔH69/ΔV70 single mutant had two-fold higher infectivity compared to wild type, possibly compensating for the reduced infectivity of D796H. These data reveal strong selection on SARS-CoV-2 during convalescent plasma therapy associated with emergence of viral variants with evidence of reduced susceptibility to neutralising antibodies.

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Explanations of relationships between migration and environmental change now focus on multiple interactions, risks in destination and immobility. This research applies behavioural migration theory to examine the extent to which immobile populations experiencing environmental degradation exercise agency with respect to location and, in doing so, elucidates what it means to be trapped. This research uses individual survey data from a migrant-sending area in highland Peru where the population experiences negative health and livelihood impacts from climate-related phenomena. Analysis of these data reveals three reasons for nonmigration: high levels of satisfaction, resource barriers and low mobility potential. Immobility in dissatisfied people is more likely to be caused by attachment to place than resource constraints. Thus, the results suggest that trapped populations exist along a continuum. This highlights the need for policy responses differentiated by the mobility characteristics and preferences of the individual. Caution, therefore, must be exercised when labelling populations as trapped and promoting relocation.

Climate migration myths Misleading claims about mass migration induced by climate change continue to surface in both academia and policy. This requires a new research agenda on 'climate mobilities' that moves beyond simplistic assumptions and more accurately advances knowledge of the nexus between human mobility and climate change.

Integrated assessment of social and environmental sustainability dynamics in the Ganges-Brahmaputra-Meghna delta, Bangladesh Nicholls, R. J.; Hutton, C. W.; Lazar, A. N.; Allan, A.; Adger, W. N.; Adams, H.; Wolf, J.; Rahman, M.; Salehin, M. Published in:Estuarine, Coastal and Shelf Science DOI:10.1016/j.ecss.2016.08.017 Publication date: 2016 Document Version Peer reviewed version Link to publication in Discovery Research PortalCitation for published version (APA): Nicholls, R. J., Hutton, C. W., Lazar, A. N., Allan, A., Adger, W. N., Adams, H., ... Salehin, M. (2016). Integrated assessment of social and environmental sustainability dynamics in the Ganges-Brahmaputra-Meghna delta, Bangladesh. Estuarine, Coastal and Shelf Science, 183(B), 370-381. https://doi.org/10.1016/j.ecss.2016.08.017 General rightsCopyright and moral rights for the publications made accessible in Discovery Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from Discovery Research Portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain.• You may freely distribute the URL identifying the publication in the public portal. Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Abstract: Deltas provide diverse ecosystem services and benefits for their populations. At the same time, deltas are also recognised as one of the most vulnerable coastal environments, with a range of drivers operating at multiple scales, from global climate change and sea-level rise to deltaic-scale subsidence and land cover change. These drivers threaten these ecosystem services, which often provide livelihoods for the poorest communities in these regions. The imperative to maintain ecosystem services presents a development challenge: how to develop deltaic areas in ways that are sustainable and benefit all residents including the most vulnerable. Here we present an integrated framework to analyse changing ecosystem services in deltas and the implications for human well-being, focussing in particular on the provisioning ecosystem services of agriculture, inland and offshore capture fisheries, aquaculture and mangroves that directly support livelihoods. The framework is applied to the world's most populated delta, the GangesBrahmaputra-Meghna Delta within Bangladesh. The framework adopts a systemic perspective to represent the principal biophysical and socioecological components and their interaction. A range of methods are integrated within a quantitative framework, including biophysical and socio-economic modelling and analyses of governance through scenario development. The approach is iterative, with learning both within the pro...