Urticaria is one of the most common dermatologic allergic diseases, but also holds a significant psychosocial burden due to possible long duration, frequent relapses, unknown cause or trigger and resistance to applied therapy. Many patients associate the onset and worsening of the disease with stressful experiences indicating it can be a psychosomatic disease within the psychoneuroimmunological approach. Apart from that, urticaria greatly affects the quality of life (QoL) of patients, disrupts their daily lives in all aspects, and is a dermatological disease with one of the highest prevalence of psychiatric comorbidities. Therefore, in this review article we discuss why a multidisciplinary approach, which includes both biological, psychological and social aspects of the disease, must be acknowledged for effective treatment. Finally, we provide suggestions for clinical management of patients suffering from urticaria.

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