No abstract

No abstract

Previous-work has uncovered the existence of an Escherichia coli locus, groE, that is essential for bacterial growth,

The K light chain genes from two mutant hybridoma cell lines defective in K light chain synthesis were isolated and compared to the wild-type K light chain gene. In each case, the mutant K light chain genes-were found to contain repetitive DNA elements-in their intervening sequences that were not present in the intervening sequences of the wild-type K light chain gene. These elements were found to be related to the genes of intracisternal A particles. These results suggest that the decreased production of K light chain in the mutant cell lines is due to the presence of the intracisternal A particle-related genes.