CV Renjana Offset is a line of business engaged in the printing business sector using the offset printing method. Overall, the orders that CV Renjana Offset received were books so that the SM 74 printing machine became the main and very reliable machine. Even though the SpeedMaster 74 machine has been repaired monthly, the Speed Master 74 still faces a breakdown during working hours and downtime will occur. During the period from October 2021 to March 2022, ten breakdowns have occurred with a total time of 19.5 hours of downtime. This study aims to find out about the effectiveness of the performance of SpeedMaster 74. Overall Equipment Effectiveness is an approach in measuring the performance and effectiveness of the machine used. Furthermore, to find the cause of the lack of effectiveness, the calculation of Six Big Losses will be used, which is useful for knowing the most dominant factor. Both of these approaches are measuring tools in the success of implementing Total Productive Maintenance. Overall Equipment Effectiveness of SpeedMaster 74 machines in October 2021 -March 2022 has an average of 84.66%. With this value < the OEE world class standard, which is 85%. The biggest losses are Set Up and Adjustment Losses, which are 36.68% and Reduced Speed Losses, which are 35.24%.