Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by a new type of coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2). This study was conducted to determine the effectiveness of the use of Remdesivir on the outcomes of COVID-19 patients at Embung Fatimah Hospital, Batam City. Remdesivir is the first drug to be approved by the US Food and Drug Administration (USFDA) as an Emergency Use Authorization (EUA) for hospital treatment administered to COVID-19 patients. This type of research is descriptive analytic with retrospective data collection. The analysis uses the Chi-square test to see the relationship between variables. The results obtained based on the gender of male patients by 53%, based on the age of 46-55 years by 32%, and based on the length of treatment the most days were found to be less than 14 days by 65%. The number of uses of Remdesivir in each COVID-19 patient is different, the highest result in the number of uses is less than equal to 6 injections by 81%, with the dose given is 200 mg on the first day, followed by 100 mg on day 2- 5. The results of the Chi-square test with a p-value of 0.029 show that the use of Remdesivir on the outcome of COVID-19 patients can be used.

Melastoma malabathricum L. leaves is a traditional plant native to tropical Asia, subtropical, and Pacific islands. This study aimed to investigate the antibacterial activity of senduduk leaves (Melastoma malabathricum L.) against bacteria Streptococcus pyogenes,and Klebsiella pneumonia. Method of extraction done by maceration using ethanol 70% to get the extract. The antibacterial activity of the extracts was determined by using Kirby-Bauer Disc Susceptibility Test and with a concentration of 25%, 50% and, 75%. The inhibition zone was recorded from senduduk leaves (Melastoma malabathricum L.) extract to indicate the highest antimicrobial activity from this plant. Based on the results of this study, the extract leaves can inhibit the growth of Streptococcus pyogenes in concentration 75% (21.8 mm) and Klebsiella pneumonia in concentration 75% (16 mm). The phytochemical analysis detected the presence of alkaloids, flavonoids, saponins, tannins, and terpenoids. The findings may be helpful to future investigators in identifying alternative and new bioactive secondary metabolites like antibiotics to treat resistant human pathogens.