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A case of antithrombin-III (AT-III) deficiency was diagnosed on the basis of a diminished anticoagulant effect following the administration of heparin for cardiopulmonary bypass. The clinical evaluation and interpretation of a diminished response to heparin is discussed, as are considerations relative to the treatment of AT-III deficient persons whose disorder is not manifest until they are already anesthetized for cardiovascular bypass. The implications of AT-III deficiency relative to the mechanism of heparin rebound are also discussed.

Twenty‐two cases of radiation induced neoplasms following curative therapy for retinoblastoma are reviewed, and three new cases are reported. Twenty‐four of the 25 growths were malignant, and most were of the osteogenic series and its variants. The young age of the patients at the time of radiotherapy had no apparent effect upon the length of the latent interval, as persons receiving radiotherapy in adulthood had similar latent periods preceding the development of similar tumors. The prognosis of these tumors was exceptionally poor, in part due to the large proportion of sarcomas and also due to the proximity of the tumors to the deep structures of the face and base of the skull.

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