Radiation-induced neoplasms following curative therapy for retinoblastoma

Soloway, Henry B.

doi:10.1002/1097-0142(196612)19:12<1984::aid-cncr2820191225>3.0.co;2-8

Cited by 94 publications

(10 citation statements)

References 14 publications

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“…Second malignancy is also concerning and has been the subject of many reports (Forrest 1961; Soloway 1966; Smith et al. 1993; Kroll et al.…”

Section: Complications Of Ocular and Periocular Radiotherapymentioning

confidence: 99%

“…Second malignancy is also concerning and has been the subject of many reports (Forrest 1961;Soloway 1966;Smith et al 1993;Kroll et al 1994;Scaradavou et al 1995;Rich et al 1997;Raney et al 1999;Matsumoto et al 2002). A Japanese survey found that of 2000 patients who had received radiotherapy for various indications (not only ocular or periorbital disease), 54 developed second malignancies.…”

Section: Secondary Neoplasiamentioning

confidence: 99%

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Ophthalmic and adnexal complications of radiotherapy

Durkin

Roos

Higgs

et al. 2006

Acta Ophthalmologica Scandinavica

136

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ABSTRACT.The role of radiotherapy in ophthalmic practice continues to grow. This growth has seen an expansion of indications for radiotherapy, a refinement of the modalities that can be used and a reduction in the ocular and adnexal complications that result from this form of therapy. The compendium of indications for radiotherapy in ophthalmology continues to grow and now includes many conditions such as the treatment of lid and adnexal disease, ocular surface disorders and both benign and malignant disease of the posterior segment and optic pathways. The radiotherapeutic modalities employed to manage these conditions are numerous and include both radioactive plaques (brachytherapy) and external beam radiation techniques. New techniques such as stereotactic radiosurgery are delivering benefits in the management of conditions such as optic nerve sheath meningioma, where the treatment of this blinding and occasionally life-threatening intracranial neoplasm now results in fewer adverse affects. The purpose of this review is to give a brief overview of the indications and treatment modalities, and a more in-depth discussion of the potential side-effects when radiotherapy is used for ocular and periorbital disease.

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“…Second malignancy is also concerning and has been the subject of many reports (Forrest 1961; Soloway 1966; Smith et al. 1993; Kroll et al.…”

Section: Complications Of Ocular and Periocular Radiotherapymentioning

confidence: 99%

Section: Secondary Neoplasiamentioning

confidence: 99%

Ophthalmic and adnexal complications of radiotherapy

Durkin

Roos

Higgs

et al. 2006

Acta Ophthalmologica Scandinavica

136

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“…We found that an early age of exposure to radiation did not effect the latency period in nine patients who received radiation prior to age 18 for various disorders, supporting Soloway's similar observation in 24 malignant neoplasms arising secondarily to radiation therapy for retinoblastoma. 6 The effect of radiation on induction of secondary neoplasms in children with retinoblastoma is further complicated by reports associating bilateral retinoblastomas with osteosarcomas and, possibly, with other genetic-relating malignan~ies.~'…”

Section: Cancer December 1 1988mentioning

confidence: 99%

Postradiation soft tissue sarcomas: An analysis of 53 cases

Laskin

Silverman

Enzinger

1988

Cancer

330

156

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The clinicopathologic features of 53 cases of postradiation soft tissue sarcoma (PRS) were correlated with the physical characteristics of the administered radiation. All but three patients received radiation for malignant processes. Of the secondary sarcomas, malignant fibrous histiocytoma (MFH) accounted for 36 cases (68%), followed by seven extraskeletal osteosarcomas (13%), six fibrosarcomas (ll%), two malignant Schwannomas (4%), one extraskeletal chondrosarcoma, and one angiosarcoma. The sex incidence, age of the patient at time of diagnosis, and location of the PRS correlated only with the clinical characteristics of the initial treated condition. The latency period (mean 10 years) showed an indefinite relationship to patient survival but no definite relationship to the patient's age at the time of the initial radiation. There was no difference between patients treated with megavoltage radiation (39 patients) and with or-thovoltage radiation (seven patients) in the type of sarcoma, location, or survival, although the orthovoltage group received a lower mean radiation dose (3880 rads) than the megavoltage group (4446 rads). Mega-voltage radiation, however, produced deeper tissue radiation changes and was associated with a shorter latency period. Most PRS were poorly differentiated, produced abundant collagen, and had a dismal prognosis. Cancer 622330-2340,1988. HERAPEUTIC RADIATION has long been recognized T as an inducing agent in the development of malignant neoplasms ever since 1902 when Frieben' reported a case of squamous cell carcinoma arising in the hand of an x-ray technician. Previous reports dealt primarily with postradiation carcinomas or bone tumors, but rarely with soft tissue sarcomas. However, as early as 1904, Perthes2 described a spindle cell sarcoma that followed radiation therapy for lupus. In 1907, Coenen' concluded that 12% of radiation-induced tumors were sarcomas, and one year later, Marie, Clunet, and Ravlot-LaPointe4 provided experimental proof by inducing sarcomas in irradiated rats. To date, only a few reports on postradiation sarcomas have attempted correlating the various radiobiologic parameters used in clinical practice with the development and histopathology of soft tissue ' The reasons for such a dearth of useful correlative information stem from the long latency period experienced with most post

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“…It is also notable that hematologic malignancies, leukemia and/or lymphoma, may be associated with a second malignancy as the result of increased patient survival due to recent advances in the treatment of cancer. [17][18][19][20][21] In those patients, mostly in children, a notable association of glioma with leukemia or lymphoma was reported following an interval of several years remission after treatment with prophylactic radiation combined with intrathecal MTX. 17,18 Sarcoma or meningioma can also occur after being latent longer than glioma in post-radiation patients, called 'radiation-induced neoplasms'.…”

mentioning

confidence: 99%

“…17,18 Sarcoma or meningioma can also occur after being latent longer than glioma in post-radiation patients, called 'radiation-induced neoplasms'. 19 In cases of infantile leukemia/lymphoma it was postulated that cytotoxicities due to administration of immunosupressants and/or antitumor agents, the later effect of irradiation, and/or genetic susceptibility have all been encountered. However, no information is available to date with reference to adult patients with leukemia/lymphoma, especially in cases of ATL-L.…”

mentioning

confidence: 99%

Adult T‐cell lymphoma involving the leptomeninges associated with a spinal cord schwannoma

et al. 2001

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Adult T-cell lymphoma (ATL-L) developing initially in the meninges is rare. An autopsy case of ATL-L with an acute onset of meningitis and generalized lymphadenopathy in association with a cervical cord schwannoma is reported here. A 78-year-old woman with sensori-motor weakness of both arms over a 1-year period, developed febrile episodes and drowsiness with neck stiffness. Lumbar puncture revealed an increased protein content (161 mg/dL) and increased cell count (463/3) consisting of 99% of lymphocytes which contained atypical lymphocytes with multilobulated nuclei ('flower cells'), which are characteristic of ATL-L. Viral titers were positive only for HTLV-I antibodies (serum X 640: CSF X 16). Biopsy of an enlarged retroperitoneal lymph node revealed malignant lymphoma of the T-cell type. Brain MRI was negative, whereas an intradural extramedullary mass was found at the C4 level. With a diagnosis of ATL-L stage IV, chemotherapy was commenced, which was effective in reducing the generalized lymphadenopathy as well as the cervical mass and restoring the CSF findings to normality. The cervical cord mass was verified to be a solitary schwannoma, and ATL-L involvement was found not only in the leptomeninges, but also within the cervical cord schwannoma.

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Radiation-induced neoplasms following curative therapy for retinoblastoma

Cited by 94 publications

References 14 publications

Ophthalmic and adnexal complications of radiotherapy

Ophthalmic and adnexal complications of radiotherapy

Postradiation soft tissue sarcomas: An analysis of 53 cases

Adult T‐cell lymphoma involving the leptomeninges associated with a spinal cord schwannoma

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