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The following case is presented because it is believed to be the first reported instance of "double appendix" arising as a congenital malformation and unassociated with inflammation. This and other anomalies of the intestinal tract in the patient bear a striking resemblance to the avian alimentary tract. "Double appendix" appears in quotation marks, for the "appendixes" are believed to be the homologs of avian ceca rather than true appendixes. The possibility of two appendixes in one person may have important medicolegal significance.A summary of the clinical data and a condensation of the pathologic report follow : REPORT OF CASEHistory.\p=m-\L.A., a white male infant, entered the hospital on July 29, 1931, at the age of 11 hours, because of an imperforate anus. He was born at full term; the delivery was normal. X-ray plates taken with the patient in an inverted position showed no air-filled intestine in the pelvis or near the anus. On this evidence a sigmoidostomy was performed, with immediate evacuation of a considerable amount of meconium.Course.-After operation, the patient ran a septic type of temperature. Irriga¬ tions were continued through the Mixter tube, and bowel movements were normal in number by this route. The patient went gradually downhill and died on August 13, fifteen days after entry.The urine contained from 2 to 3 white cells per high power field. The clinical diagnosis was imperforate anus. Autopsy.-This was performed at the Children's Hospital on August 13, four hours post mortem. There were no restrictions.Body : The body was that of a well developed and moderately well nourished, white, male infant measuring 52.5 cm. in length. Rigor mortis was moderate in the hands and jaw and was otherwise absent. Postmortem lividity was slight in the dependent portions. There were no skeletal deformities. The lips were cyanotic. The abdomen was flat, and no organs could be palpated. There was a right rectus operative incision measuring 4 cm. in length. There were no sutures or drainage tubes. The wound was wide open, and loops of intestine could be seen beneath it. The edges were indurated and reddened. The anus was imperforate, being represented by a dimple in the skin not more than 0.5 cm. deep. The body was otherwise normal.

Summary and Conclusions In 42 albino rats sensitized to horse serum or egg albumen by large multiple doses, only 2 failed to show some observable signs or pathological changes of anaphylactic shock. However, the individual variation in susceptibility was great. In general, shock was clinically more striking in small or malnourished rats, while in adults the in vivo signs might be entirely lacking and yet the pathological changes be typical. A bread diet did not increase the susceptibility to shock. The pathological changes of anaphylactic shock in the rat consist of venous congestion, edema, hemorrhage, and eosinophilia, being most extensive in the upper intestinal tract. In some instances at least, the typical pathology of experimental asthma was produced. Specific Dale uterine reactions could not be obtained, although occasional non-specific contractions were noted. Histamine in a dilution of 1:7500 caused a good, sustained contraction of the excised uterus, whereas a dilution of 1:1,000,000 produced relaxation of tone and inhibition of rhythmicity as reported by others. Rats uniformly produce precipitins when large, multiple doses of horse serum or egg albumen are administered. The measurable weight of the rat's adrenal gland is unaffected by shock or bread diet.