165gross finding was a large fatty liver. No adenoma of pancreatic islet tissue could be found.It is our tentative opinion that the fundamental defect here is probably an inability to form glycogen. A pancreatic islet tumour with consequent hyperinsulinism was ruled out by the increase in blood sugar after ingestion of glucose. A diet rich in carbohydrate was taken without the development of glycosuria indicating the ability to burn sugar. This fact was further confirmed by the absence of ketone bodies in the urine. Failure to form glycogen would explain the marked fatty infiltration of the liver and the failure of the infant to respond to adrenalin. This case recalls the experiments of MANN on hepatectomized dogs and those of COLLINS, SHELLING and BYRON in which removal of the liver in the f i r s t instance, or ligation of the hepatic artery in tho second, produced a progressive fall in blood-sugar which adrenalin did not overcome, these animals dying in convulsions.The attempt has been made to compare different fats both as regards their ease of assimilation by infants and their fate after absorption. Comparative data on absorption are meagre and open to the criticism that factors other than fat have been varied. We have employed a standard basal feeding of fat-free milk in which various fats have been incorporated by homogenization; all feeclings were autoclaved; vitamins were supplied independently.The observations include a study of the effect of other con\-ponents of the diet on fat retention, and also the effect of alterations in the physical and chemical properties of the fat itself.The effect of minerals on fat retention has been studied at 3 levels of mineral intake. The fat was incorporated: 1) in fat-free breast inilk to afford a low mineral intake, 2) in fat-free cow's milk and 3) in fat-free cow's inilk to which a salt, mixture has been added approximat,ely doubling the concentration of each mineral ingredient. Observations made both with butter fat and breast milk fat illustrate the inverse relatrionsliip between mineral inta>ke and fat retention. I.

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