We perform gas flow experiments in a shallow microchannel, 1.14±0.02 μm deep, 200 μm wide, etched in glass and covered by an atomically flat silicon wafer. The dimensions of the channel are accurately measured by using profilometry, optical microscopy and interferometric optical microscopy. Flow-rate and pressure drop measurements are performed for helium and nitrogen, in a range of averaged Knudsen numbers extending up to 0.8 for helium and 0.6 for nitrogen. This represents an extension, by a factor of 3 or so, of previous studies. We emphasize the importance of the averaged Knudsen number which is identified as the basic control parameter of the problem. From the measurements, we estimate the accommodation factor for helium to be equal to 0.91±0.03 and that for nitrogen equal to 0.87±0.06. We provide estimates for second-order effects, and compare them with theoretical expectations. We estimate the upper limit of the slip flow regime, in terms of the averaged Knudsen number, to be 0.3±0.1, for the two gases.

We show that wetting properties crucially control the patterns in two-phase flows of immiscible fluids in microchannels. Ordered patterns, continuously entrained by the flow, are obtained when one phase completely wets the walls, while disordered patterns, intermittently adhering to the channel walls, are unavoidably produced when wetting is partial. A lower limit for the channel sizes capable of generating well structured objects (drops, pears, pearl necklaces, ...) is presented.

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Nanoscale mesoporous iron carboxylates metal-organic frameworks (nanoMOFs) have recently emerged as promising platforms for drug delivery, showing biodegradability, biocompatibility and important loading capability of challenging highly water-soluble drugs such as azidothymidine tryphosphate (AZT-TP). In this study, nanoMOFs made of iron trimesate (MIL-100) were able to act as efficient molecular sponges, quickly adsorbing up to 24 wt% AZT-TP with entrapment efficiencies close to 100%, without perturbation of the supramolecular crystalline organization. These data are in agreement with molecular modelling predictions, indicating maximal loadings of 33 wt% and preferential location of the drug in the large cages. Spectrophotometry, isothermal titration calorimetry, and solid state NMR investigations enable to gain insight on the mechanism of interaction of AZT and AZT-TP with the nanoMOFs, pointing out the crucial role of phosphates strongly coordinating with the unsaturated iron(III) sites. Finally, contrarily to the free AZT-TP, the loaded nanoparticles efficiently penetrate and release their cargo of active triphosphorylated AZT inside major HIV target cells, efficiently protecting against HIV infection.