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This work was designed to examine the effect of butylphthalide (BuPh) on the duration of anesthesia induced by intraperitoneal injection of pentobarbital in adult male ddy mice. Anesthetic period was measured by the duration of loss of righting reflex. Administration of sodium pentobarbital (50 mg/ kg, i.p.) induced anesthesia lasting for about 28 min. Inhalation of BuPh during anesthesia markedly increased the duration of anesthesia. When the nasal cavity of animal was infused with 5% zinc sulfate in 0.5% NaCl 2 days prior to BuPh inhalation, such an increase was not observed, whereas infusion with 0.5% NaCl alone did not abolish the effect of BuPh. Histologically, zinc sulfate infusion caused a severe damage to the olfactory mucous membrane. The results suggest that BuPh potentiates the effect of pentobarbital via the olfactory pathway.

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