The duration of tuberculosis treatment affects patient adherence. The pharmacist monitors the patient's medication by providing an intervention in the form of a reminder card. The research objective was to use a reminder card to determine the compliance level of tuberculosis patients. The design of this study was a pre-experimental one group pretest-post test from December 2019 - January 2020. The study sample was 133 adult tuberculosis patients who received detached drugs and had undergone treatment >1 month at the Pulmonary Poly Outpatient Waluyo Jati Kraksaan Hospital. The level of adherence with the reminder card intervention was calculated using the pill count method and analyzed using the Wilcoxon test. The result of tuberculosis patient adherence level increased significantly (p<0.05) after giving the reminder card from 50.00% to 99.37%. Providing a reminder card is an effort that can improve adherence to treatment of tuberculosis patients.