A naturalistic, uncontrolled follow-up study was carried out in 70 male alcohol dependent patients, in the Department of Psychiatry, RIMS, Imphal from May, 2005 to October, 2006. The author is aiming to evaluate the efficacy of TOPIRAMATE as anti-craving agent and also evaluate the treatment outcome at the end of one year. The study has been well designed and carried out meticulously. The severity of alcohol dependence data questionnaires (SADD) and Michigan alcohol screening test (MAST) was applied after detoxification. Out of 70 subjects, 35 subjects were given topiramate as anti-craving drug. At the end of one year follow-up study, 34.3% of the subjects could be classified under the abstinent and non-problem drinker, 34.3% continue to drink but showed improvement in social and occupational functioning and 31.4% showed no improvement.