We investigated the time evolution of a strong collisionless shock in counterstreaming plasmas produced using a high-power laser pulse. The counterstreaming plasmas were generated by irradiating a CH double-plane target with the laser. In self-emission streaked optical pyrometry data, steepening of the self-emission profile as the two-plasma interaction evolved indicated shock formation. The shock thickness was less than the mean free path of the counterstreaming ions. Two-dimensional snapshots of the self-emission and shadowgrams also showed very thin shock structures. The Mach numbers estimated from the flow velocity and the brightness temperatures are very high.

The experimental demonstration of the formation of a strong electrostatic (ES) collisionless shock has been carried out with high-speed counterstreaming plasmas, produced by a high-power laser irradiation, without external magnetic field. The nearly four times density jump observed in the experiment shows a high Mach-number shock. This large density jump is attributed to the compression of the downstream plasma by momentum transfer by ion reflection of the upstream plasma. Particle-in-cell (PIC) simulation shows the production of a collisionless high Mach-number ES shock with counterstreaming interaction of two plasma slabs with different temperatures and densities, as pointed out by Sorasio et al. [Phys. Rev. Lett. 96, 045005 (2006)]. It is speculated that the shock discontinuity is balanced with the momentum of incoming and reflected ions and the predominant pressure of the electrons in the downstream with PIC simulation.

Atmospheric-pressure plasmas were produced on the surface of liquid water by radio-frequency (RF) power supply. A quartz chamber with an off-center inner electrode was used to generate discharges with a wide range of filling gas pressures. When the chamber was filled with fuel gas and liquid water and a sufficient RF power was supplied to the system, plasmas were observed to be produced around the inner electrode as well as on the water surface. Optical emission spectroscopy (OES) identified the generation of oxidative hydroxyl (OH) radicals and decoloration of methylene blue in the solution demonstrated oxidative capacity of water plasmas generated in this system.

Aberrant DNA methylation could potentially serve as a biomarker for colorectal neoplasms. In this study, we assessed the feasibility of using DNA methylation detected in bowel lavage fluid (BLF) for colorectal cancer screening. A total of 508 BLF specimens were collected from patients with colorectal cancer (n ¼ 56), advanced adenoma (n ¼ 53), minor polyp (n ¼ 209), and healthy individuals (n ¼ 190) undergoing colonoscopy. Methylation of 15 genes (miR-1-1, miR-9-1, miR-9-3, miR-34b/c, miR-124-1, miR-124-2, miR-124-3, miR-137, SFRP1, SFRP2, APC, DKK2, WIF1, LOC386758, and ZNF582) was then analyzed in MethyLight assays, after which receiver operating characteristic (ROC) curves were analyzed to assess the diagnostic performance of BLF methylation. Through analyzing BLF specimens in a training set (n ¼ 345), we selected the three genes showing the greatest sensitivity for colorectal cancer detection (miR-124-3, 71.8%; LOC386758, 79.5%; and SFRP1, 74.4%). A scoring system based on the methylation of those three genes (M-score) achieved 82% sensitivity and 79% specificity, and the area under the ROC curve (AUC) was 0.834. The strong performance of this system was then validated in an independent test set (n ¼ 153; AUC ¼ 0.808). No significant correlation was found between M-score and the clinicopathologic features of the colorectal cancers. Our results demonstrate that DNA methylation in BLF specimens may be a useful biomarker for the detection of colorectal cancer. Cancer Prev Res; 7(10);