Two cases of coronary aneurysm developed in the late period after Kawasaki disease (KD). Case 1 involved a 13-year-old boy who had aneurysms develop after a diagnosis of complete regression. Case 2 involved a 29-year-old man who had a new aneurysm develop after he was older than 20 years. Physicians need to be aware that coronary aneurysms can develop in patients with antecedent KD even after regression or in adulthood.
Histological results reveal that coronary arteritis begins 6-8 days after onset and progresses to pan-vasculitis on approximately day 10 of acute KD. Aneurysms develop on or around day 12, and are accompanied by destruction of the internal elastic lamina and media. 5 Smooth muscle cells (SMCs) are observed in the intima in acute KD vasculitis and are considered to contribute to vasculitis progression. 6 LR11, which is a member of the low-density lipoprotein (LDL) receptor family, is markedly expressed in vascular SMCs that are present in the intima of atherosclerotic K awasaki disease (KD) is an acute, self-limited generalized systemic vasculitis that is most common in children under 5 years of age. Although more than 50 years have passed since KD was first reported by Dr. Tomisaku Kawasaki in 1967, 1 its etiology remains unknown. KD causes inflammation in the walls of medium-sized arteries, particularly the coronary artery. Coronary artery lesions (CALs) occur in 20-25% of untreated KD patients, and include aneurysms, stenosis, and occlusion, which are its most critical complications. These critical complications may lead to myocardial infarction or cardiac death. 2,3 KD is the leading cause of acquired heart disease among children in developed countries. 4Editorial p ????
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