Purpose: To investigate the penetration enhancing effect of two polysorbates -polyoxyethylene 20

Purpose:To evaluate the effect of a topical application of a cream formulation containing extract of Acacia nilotica bark extract on human cheek skin texture. Methods: A cream containing 3 % concentrated extract of Acacia nilotica bark was developed by entrapping the extract in the internal aqueous phase of the cream having strong antioxidant activity. A similar cream but without the extract was also prepared. Each of the formulations was applied to the cheeks of 11 human volunteers for a period of three months. Both cream formulations were assessed, using Visioscan VC 98, for various parameters including texture parameters (energy, contrast and variance) as well as for skin roughness (Ser), skin scaliness (SEsc), skin smoothness (SEsm) and skin wrinkles (Sew). Results: Unlike the cream base, the extract cream exhibited steady, significant improvement in skin parameters over the 3-month period of application. Images showed visible improvement of the overall skin appearance and reduction of fine lines by the extract cream. Furthermore, skin texture (variance and contrast) and SELS (SEr, SEsc, SEsm and SEw) parameters showed significant decline (p < 0.05) and the texture parameter of energy showed significant increase (p < 0.05). Conclusion: Our findings indicate that the cream containing 3 % Acacia nilotica bark extract possesses anti-aging effect and improves skin surface appearance..

Purpose: To determine the antioxidant activity of Crucus sativus extract and its effect on human skin using a non-invasive probe mexameter. Methods: The antioxidant activity of C. sativus extract was determined using DPPH method. Water in oil (w/o) topical cream of C. sativus extract (3 %) was formulated and compared with the base (cream without extract). Both creams (formulation and base) were applied to the cheeks of 10 healthy human volunteers for a period of 8 weeks. Melanin and erythema values of skin were measured with a mexameter. Results:The antioxidant activity of the extract was 81 %. Change in the levels of skin melanin and erythema was -24.04 ± 3.23 and -13.57 ± 2.28, respectively, indicating

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