The Center for Hydrometeorology and Remote Sensing (CHRS) has created the CHRS Data Portal to facilitate easy access to the three open data licensed satellite-based precipitation datasets generated by our Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks (PERSIANN) system: PERSIANN, PERSIANN-Cloud Classification System (CCS), and PERSIANN-Climate Data Record (CDR). These datasets have the potential for widespread use by various researchers, professionals including engineers, city planners, and so forth, as well as the community at large. Researchers at CHRS created the CHRS Data Portal with an emphasis on simplicity and the intention of fostering synergistic relationships with scientists and experts from around the world. The following paper presents an outline of the hosted datasets and features available on the CHRS Data Portal, an examination of the necessity of easily accessible public data, a comprehensive overview of the PERSIANN algorithms and datasets, and a walk-through of the procedure to access and obtain the data.

Little dispute surrounds the observed global temperature changes over the past decades. As a result, there is widespread agreement that a corresponding response in the global hydrologic cycle must exist. However, exactly how such a response manifests remains unsettled. Here we use a unique recently developed long-term satellite-based record to assess changes in precipitation across spatial scales. We show that warm climate regions exhibit decreasing precipitation trends, while arid and polar climate regions show increasing trends. At the country scale, precipitation seems to have increased in 96 countries, and decreased in 104. We also explore precipitation changes over 237 global major basins. Our results show opposing trends at different scales, highlighting the importance of spatial scale in trend analysis. Furthermore, while the increasing global temperature trend is apparent in observations, the same cannot be said for the global precipitation trend according to the high-resolution dataset, PERSIANN-CDR, used in this study.

This article presents a cloud-free snow cover dataset with a daily temporal resolution and 0.05° spatial resolution from March 2000 to February 2017 over the contiguous United States (CONUS). The dataset was developed by completely removing clouds from the original NASA’s Moderate Resolution Imaging Spectroradiometer (MODIS) Snow Cover Area product (MOD10C1) through a series of spatiotemporal filters followed by the Variational Interpolation (VI) algorithm; the filters and VI algorithm were evaluated using bootstrapping test. The dataset was validated over the period with the Landsat 7 ETM+ snow cover maps in the Seattle, Minneapolis, Rocky Mountains, and Sierra Nevada regions. The resulting cloud-free snow cover captured accurately dynamic changes of snow throughout the period in terms of Probability of Detection (POD) and False Alarm Ratio (FAR) with average values of 0.955 and 0.179 for POD and FAR, respectively. The dataset provides continuous inputs of snow cover area for hydrologic studies for almost two decades. The VI algorithm can be applied in other regions given that a proper validation can be performed.

ErbB3 is an important regulator of tumorigenesis and is implicated in development of resistance to several currently used oncology drugs. We have identified ErbB3 inhibitors based on a novel biologic scaffold termed a surrobody. Two of these inhibitors appear to work by a previously unrecognized mechanism of action. As a consequence, they not only inhibited cell proliferation and intracellular signaling driven by stimulation with the ErbB3 ligand neuregulin (NRG), but also inhibited signaling and proliferation that was driven by overexpression of ErbB2 in the absence of ligand stimulation. In addition, the surrobodies inhibited tumor growth in vivo in both ErbB2-overexpressing and nonoverexpressing cells. In ErbB2-overexpressing cells, both of the anti-ErbB3 surrobodies significantly augmented the activities of trastuzumab, lapatinib, and GDC-0941, agents that inhibit cell proliferation by different mechanisms. Moreover, although NRG diminished the efficacy of these agents, when they were combined with anti-ErbB3 surrobodies the affect of NRG was abrogated. In this capacity, the anti-ErbB3 surrobodies were more effective than the ErbB2/ErbB3 dimerization inhibitory antibody pertuzumab. Despite the fact that these surrobodies appear to engage ErbB3 differently than previously described anti-ErbB3 antibodies, they retain all of the beneficial characteristics of this class of agents, including the ability to augment drugs that inhibit EGF receptor. These anti-ErbB3 agents, therefore, show substantial promise for development as single agents or in combination with other ErbB-directed antibodies or small molecules and may provide for a broader range of therapeutic indications than previously described anti-ErbB3 antibodies.

The purpose of this study is to use the PERSIANN–Climate Data Record (PERSIANN-CDR) dataset to evaluate the ability of 32 CMIP5 models in capturing the behavior of daily extreme precipitation estimates globally. The daily long-term historical global PERSIANN-CDR allows for a global investigation of eight precipitation indices that is unattainable with other datasets. Quantitative comparisons against CPC daily gauge; GPCP One-Degree Daily (GPCP1DD); and TRMM 3B42, version 7 (3B42V7), datasets show the credibility of PERSIANN-CDR to be used as the reference data for global evaluation of CMIP5 models. This work uniquely defines different study regions by partitioning global land areas into 25 groups based on continent and climate zone type. Results show that model performance in warm temperate and equatorial regions in capturing daily extreme precipitation behavior is largely mixed in terms of index RMSE and correlation, suggesting that these regions may benefit from weighted model averaging schemes or model selection as opposed to simple model averaging. The three driest climate regions (snow, polar, and arid) exhibit high correlations and low RMSE values when compared against PERSIANN-CDR estimates, with the exceptions of the cold regions showing an inability to capture the 95th and 99th percentile annual total precipitation characteristics. A comprehensive assessment of each model’s performance in each continent–climate zone defined group is provided as a guide for both model developers to target regions and processes that are not yet fully captured in certain climate types, and for climate model output users to be able to select the models and/or the study areas that may best fit their applications of interest.