Pupil campimetry is an objective test of the visual field. In pupil campimetry, the pupil light response elicited by focal light stimuli at different locations within the visual field is measured. Pupil campimetry was performed in patients with visual field loss because of different pathologies. The match between reduced pupil response and visual field loss was assessed. The pupil field of 23 patients was recorded by infrared video-pupillography with light stimuli generated on a computer screen. A visual field was obtained on the same day with the Tuebingen Automated Perimeter. Both fields were compared by subjective judgement. Six of nine patients with large, two of five patients with incomplete, and three of six patients with minor field loss showed matching defects in their pupil and their visual fields. In functional loss of visual field sensitivity, no pupil field defect was seen (three patients). In most patients, the loss of visual field sensitivity could be revealed objectively by pupil campimetry.

Purpose: To evaluate the effect of a novel technique to correct presbyopia. A phakic IOL (presbyopic IPCL; implantable phakic contact lens) with a diffractive optic is implanted and its impact on visual acuity, refraction, patient satisfaction in patients striving for spectacleindependence is evaluated. Design: Retrospective noncomparative open-label clinical trial. Methods: Sixteen eyes of 8 patients (average age 47 years) had a presbyopic IPCL implanted in the posterior chamber. The visual acuity on different distances, refractive status, corneal topography, endothelial cell density, anterior chamber depth, white-to-white, mesopic pupil size and intraocular pressure (IOP) were measured before implantation of this novel phakic IOL with diffractive optic and four weeks after surgery. Results: At follow-up four weeks after surgery, 9 of the 16 eyes were emmetropic and uncorrected distance visual acuity was at least 0.8. Near vision was excellent in all patients without the need to wear reading glasses. There was neither a significant change in IOP nor a significant surgical impact on endothelial cells. Patient satisfaction was high. There was no major complaint of halos or glare. Conclusion: The presbyopic IPCL can provide the presbyopic patient with good visual acuity and spectacle-independence for far and near distance. We found this novel technique to have a good safety profile during the surgical procedure and our short follow-up period. Further long-term follow-up is mandatory.

<b><i>Background:</i></b> The aim of the study was to analyze the objective optical properties of 2 enhanced depth of focus (EDoF) intraocular lenses (IOLs) using optical bench analysis. <b><i>Methods:</i></b> This experimental study investigates 2 new EDoF IOLs, the Alcon AcrySof IQ Vivity and the Bausch &amp; Lomb LuxSmart Crystal, on the optical bench, using OptiSpheric IOL PRO2 (Trioptics, Germany) in order to assess the optical quality according to ISO 11979 with ISO-2 Cornea. IOLs (power 22.0 D) were evaluated regarding modulation transfer function (MTF) at 50 lp/mm and Strehl ratio (SR) using a 3.0-mm and a 4.5-mm aperture. In addition, wavefront measurements were obtained using WaveMaster® IOL 2 device (Trioptics, Germany), and USAF targets were analyzed. <b><i>Results:</i></b> Centered: the MTF (mean) at 50 lp/mm (AcrySof IQ Vivity/LuxSmart Crystal) with 3.0 mm aperture was 0.250/0.257 and with 4.5 mm aperture 0.202/0.243. The SR (mean) with 3.0 mm aperture was 0.261/0.355 and with 4.5 mm aperture 0.176/0.206. Decentered by 1 mm: the MTF (mean) at 50 lp/mm (AcrySof IQ Vivity/LuxSmart Crystal) with 3.0 mm aperture was 0.266/0.247 and with 4.5 mm aperture 0.126/0.215. The SR (mean) with 3.0 mm aperture was 0.272/0.234 and with 4.5 mm aperture 0.133/0.183. Tilted by 5 degree: the MTF (mean) at 50 lp/mm (AcrySof IQ Vivity/LuxSmart Crystal) with 3.0 mm aperture was 0.221/0.360 and with 4.5 mm aperture 0.214/0.229. The SR (mean) with 3.0 mm aperture was 0.232/0.428 and with 4.5 mm aperture 0.225/0.229. The simulated visual function using USAF test targets showed corresponding qualitative results. Wavefront measurements proved a complex optical design. Higher order aberrations in the central part of the optics were modulated up to the 10th order to enhance the range of functional vision to near distance, leaving the peripheral parts of the optics aberration free or as aberration correcting. <b><i>Conclusion:</i></b> The diversity of EDOF IOLs, their optics, and their respective impact on the vision quality must be understood in order to select the appropriate IOL in each individual case. This analysis of new, innovative IOL optics based on increased negative spherical aberration may help the ophthalmic surgeon to select the IOL which meets the individual requirements of the patient for best postoperative outcomes. It seems that there is no perfect IOL that is equally suitable for all patients, but the right choice is an individual, customized approach dealing with patients’ expectations.

Purpose To assess the depth of focus of four latest non-diffractive extended range of vision IOLs on the optical bench. Such comparison had not been done before. Methods We assessed and compared the through focus modulation transfer function (MTF) of the following novel IOLs with a nominal power of 22 D: Acrysof Vivity, LuxSmart Crystal, RayOne EMV and Tecnis Eyhance. An ISO-2 model eye was applied with apertures of 3 and 4.5 mm with monochromatic light of 546 nm. Measurements were done on OptiSpheric IOL PRO 2 optical bench. Results For the aperture of 3 mm, Eyhance and RayOne EMV showed the most pronounced peak in MTF with only little enlarged depth of power. Vivity and LuxSmart showed two peaks of about 1.7 D respectively 1.3 D depth of focus, yet reduced MTF and with maxima differently located. For 4.5 mm, MTF values for Eyhance and particularly for RayOne EMV dropped. For Vivity and LuxSmart, only the peak for the secondary focus decreased. Conclusion Vivity and LuxSmart showed a larger depth of focus for our measuring conditions than Eyhance and RayOne EMV. Correspondingly, the peak MTF was best for Eyhance and RayOne ERV with small aperture. With the larger aperture, RayOne EMV considerably lost performance.

Introduction The human eye is not optically symmetrical, and very few IOLs are perfectly centered in the eye. That is why contrast sensitivity can degrade in some conditions, especially in low light. In an optical bench analysis, we compare spherical (A), aberration correcting (B) and specific aspherical lenses (C) in terms of impact of decentration and tilt on the modulation transfer function as well as the simulated overall quality with USAF test targets. Material and Methods: The OptiSpheric IOL PRO2 was used to measure the optical performance of IOLs (A,B,C). In order to assess the optical quality of the IOLs, the optical quality parameters for the aperture size of 3.0 mm and 4.5 mm at the IOL plane were assessed. Through Frequency Modulation Transfer Function (MTF) and Strehl Ratio (SR) values, as well as the “US Airforce 1951 resolution test chart images” as qualitative simulation, were analyzed. All measurements (ISO) were repeated and done for centered, decentered (1mm) and tilted (5°) IOLs. Results: Centered: The MTF (mean) at 50 lp/mm (IOL A, B, C) with 3.0 mm aperture was 0.794/0.716/0.797 (ISO 1 cornea) and 0.673/0.752/0.723 (ISO 2 cornea) and with 4.5 mm aperture 0.728/0.365/0.751 (ISO 1) and 0.276/0.767/0.505 (ISO 2). The Strehl ratio (mean) with 3.0 mm aperture was 0.763/0.829/0.898 and with 4.5 mm aperture 0.228/0.386/0.432. Decentered by 1mm: The MTF (mean) at 50 lp/mm with 3.0 mm aperture was 0.779/0.459/0.726 (ISO 1) and 0.695/0.381/0.662 (ISO 2). The MTF (mean) at 50 lp/mm with 4.5 mm aperture was 0.732/0.348/0.653 (ISO 1) and 0.355/0.069/0.346 (ISO 2). The Strehl ratio (mean) with 3.0 mm aperture was 0.829/0.543/0.397 and with 4.5 mm aperture 0.259/0.145/0.192. Tilted by 5 degree: The MTF (mean) at 50 lp/mm with 3.0 mm aperture was 0.731/0.705/0.751 (ISO 1) and 0.623/0.727/0.732 (ISO 2). The MTF (mean) at 50 lp/mm with 4.5 mm aperture was 0.579/0.406/0.701 (ISO 1) and 0.277/0.512/0.429 (ISO 2). The Strehl ratio (mean) with 3.0 mm aperture 0.539/0.478/0.514 and with 4.5 mm aperture 0.262/0.136/0.201. Conclusion: Aberration correcting IOLs perform best when perfectly centered. The optical performance of aberration correcting IOLs can be markedly downgraded by misalignment. The examined ZO optic performed well in decentration and tilt. The ZO concept seems to be a good alternative to aspheric lenses, as it achieves to combine benefits of spherical and aspheric intraocular lenses. There is no perfect IOL, but fitting and choosing the right one for the individual case seems to be crucial to take advantage of benefits and minimize disadvantages. This is why knowledge of optical properties is also mandatory for the surgeon.