The flavonoid apigenin is common to many plants. Although the responsible mechanisms have yet to be elucidated, apigenin demonstrates tumor suppression in vitro and in vivo. This study uses an azoxymethane (AOM)/dextran sodium sulfate- (DSS-) induced colon cancer mouse model to investigate apigenin’s potential mechanism of action exerted through its effects upon gut microbiota. The size and quantity of tumors were reduced significantly in the apigenin treatment group. Using 16S rRNA high-throughput sequencing of fecal samples, the composition of gut microbiota was significantly affected by apigenin. Further experiments in which gut microbiota were reduced and feces were transplanted provided further evidence of apigenin-modulated gut microbiota exerting antitumor effects. Apigenin was unable to reduce the number or size of tumors when gut microbiota were depleted. Moreover, tumor inhibition effects were initiated following the transplant of feces from mice treated with apigenin. Our findings suggest that the effect of apigenin on the composition of gut microbiota can suppress tumors.

Objective To investigate the relationship between metabolic disorders and the morbidity of colorectal cancer (CRC) compared with colorectal adenoma (CRA) and non-neoplastic inpatients, especially to investigate which anthropometric measures were better predictors of CRC. Methods 80 patients with CRC, 80 patients with CRA and 80 non-neoplastic patients were selected from April 2017 to April 2019. The data of routine laboratory tests and anthropometric measurements about metabolism were analyzed retrospectively. Multinomial Logistic regression analysis was used to estimated odds ratio (OR) and 95% confidence interval (CI) for the risk of morbidity of CRC associated with potential risk factors. Results Compared with CRA, OR of CRC was enhanced by weight loss self-reported, lower-hemoglobin and hypoproteinemia. Compared with non-neoplastic controls, diabetes, higher waist-neck ratio (WNR) and The Metabolic syndrome (MetS) identifified by the Chinese Diabetes Society was associated with signifificant increasing risk of all CRC patients. while in male subgroup, OR of CRC was enhanced by diabetes, higher hip circumference, waist-neck ratio (WNR)>2.42 (OR = 2.795, 95%CI: 1.169-6.680), waist-height ratio (WHtR)>0.550 (OR = 3.009, 95%CI: 1.260-7.185) and MetS. In female subgroup, only waist-hip ratio (WHR)>0.890 (multivariable-adjusted OR = 3.354, 95%CI: 1.011-11.129) was significantly associated with increased risk of CRC compared with colorectal adenoma and non-neoplastic controls. The risk factors for CRA were similar to CRC compared with non-neoplastic controls. Conclusion Abdominal fat patients have a high incidence of CRC and CRA. For male, MetS, high level WNR and WHtR caused an increasing risk for CRC. For female, Only WHR is a high-risk factor. The patients with these high risk factors need to strengthen colorectal cancer screening, which is of great significance for the prevention and early detection of colorectal cancer.

Objective To investigate the relationship between metabolic disorders and the morbidity of colorectal cancer (CRC) compared with colorectal adenoma (CRA) and non-neoplastic inpatients, especially to investigate which anthropometric measures were better predictors of CRC. Methods 80 patients with CRC, 80 patients with CRA and 80 non-neoplastic patients were selected from April 2017 to April 2019. The data of routine laboratory tests and anthropometric measurements about metabolism were analyzed retrospectively. Multinomial Logistic regression analysis was used to estimated odds ratio (OR) and 95% confidence interval (CI) for the risk of morbidity of CRC associated with potential risk factors. Results Compared with CRA, OR of CRC was enhanced by weight loss self-reported, anemia and hypoproteinemia. Compared with non-neoplastic controls, diabetes, higher waist-neck ratio (WNR) and The Metabolic syndrome (MetS) identifified by the Chinese Diabetes Society was associated with signifificant increasing risk of all CRC patients. while in male subgroup, OR of CRC was enhanced by diabetes, higher hip circumference, waist-neck ratio (WNR)>2.42 (OR = 2.795, 95%CI: 1.169-6.680), waist-height ratio (WHtR)>0.550 (OR = 3.009, 95%CI: 1.260-7.185) and MetS. In female subgroup, only waist-hip ratio (WHR)>0.890 (multivariable-adjusted OR = 3.354, 95%CI: 1.011-11.129) was significantly associated with increased risk of CRC compared with colorectal adenoma and non-neoplastic controls. The risk factors for CRA were similar to CRC compared with non-neoplastic controls. Conclusion Visceral adipose patients have a high incidence of CRC and CRA. For male, MetS, high level WNR and WHtR caused an increasing risk for CRC. For female, Only WHR is a high-risk factor. The patients with these high risk factors need to strengthen colorectal cancer screening, which is of great significance for the prevention and early detection of colorectal cancer.