Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota

Bian, Shichang; Wan, Hongjuan; Liao, Xinyan; Wang, Weisheng

doi:10.1155/2020/7141970

Cited by 21 publications

(11 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This effect may be that apigenin increases the abundance of actinobacteria in the intestine and reduces the abundance of firmicutes . [ 36 ] Helicobacter pylori is one of the potential risks of gastric cancer. A study found apigenin prevented H. pylori ‐induced atrophic gastritis.…”

Section: The Anti‐cancer Effects Of Dietary Polyphenolsmentioning

confidence: 99%

Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention

Cao

et al. 2021

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Cancer is a serious public health problem in the world and a major disease affecting human health. Dietary polyphenols have shown good potential in the treatment of various cancers. It is worth noting that cancer cells usually exhibit metabolic abnormalities of high glucose intake and inefficient utilization. AMPK is the key molecule in the regulation of energy metabolism and is closely related with obesity and diabetes. Recent studies indicate that AMPK also plays an important role in cancer prevention and regulating cancer‐related genes and pathways, and dietary polyphenols can significantly regulate AMPK activity. In this review, the progress of dietary polyphenols preventing carcinogenesis via AMPK pathway is systemically summarized. From the viewpoint of interfering energy metabolism, the anti‐cancer effects of dietary polyphenols are explained. AMPK pathway modulated by different dietary polyphenols affects pathways and target genes are summarized. Dietary polyphenols exert anti‐cancer effect through the target molecules regulated by AMPK, which broadens the understanding of polyphenols anti‐cancer mechanisms and provides value reference for the investigators of the novel field.

show abstract

Section: The Anti‐cancer Effects Of Dietary Polyphenolsmentioning

confidence: 99%

Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention

Cao

et al. 2021

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…Apigenin significantly restrained cancer cell growth and metastasis in the murine CRC model 168 . Further investigation revealed that apigenin affected the composition of gut microbiota in mice.…”

Section: Flavonoids Gut Microbiota and Colorectal Cancermentioning

confidence: 98%

“…Therefore, apigenin could ameliorate gut microbiota dysbiosis. The transplant of feces from mice treated with apigenin suppressed colon carcinogenesis in recipient mice, suggesting that apigenin-modulated gut microbiota exerted antitumor effects 168 . These findings reinforced the relationship between the anticarcinogenic effect of apigenin and modulation of gut microbiota.…”

Section: Flavonoids Gut Microbiota and Colorectal Cancermentioning

confidence: 99%

The Effects and Mechanisms of Flavonoids on Cancer Prevention and Therapy: Focus on Gut Microbiota

Wang¹,

Yu²,

Zhang³

et al. 2022

Int. J. Biol. Sci.

View full text Add to dashboard Cite

Flavonoids are a group of polyphenolic compounds which are ubiquitously found in plants and are consumed as part of the human diet in substantial amounts. The verification of flavonoids' cancer chemopreventive benefits has led to a significant interest in this field. Gut microbiota includes a diverse community of microorganisms and has a close relationship with cancer development. Increasing evidence has indicated that flavonoids exert anticarcinogenic effects by reshaping gut microbiota. Gut microbiota can convert flavonoids into bioactive metabolites that possess anticancer activity. Here, we present a brief introduction to gut microbiota and provide an overview of the interplay between gut microbiota and cancer pathogenesis. We also highlight the crucial roles of flavonoids in preventing cancer based on their regulation of gut microbiota. This review would encourage research on the flavonoid-intestinal microbiota interactions and clinical trials to validate the chemotherapeutic potentials of targeting gut microbiota by dietary bioactive compounds.

show abstract

“…Another study showed that apigenin inhibited colon carcinogenesis induced by azoxymethane/dextran sodium sulfate by influencing the gut microbiota but the precise mechanism is also yet to be determined (Bian et al, 2020). In a different study, no protective effect was observed in a model of human gastrointestinal malignancies using ApcMin mice after treatment with dietary doses of 0.2% apigenin, which equate to approximately 300 mg/kg mice body weight (Cai et al, 2009).…”

Section: Anti Oxidant Effec Ts Of Api G Enin In C An Cer Ther Apy and Pre Venti Onmentioning

confidence: 99%

Reactive oxygen species: Key players in the anticancer effects of apigenin?

Oyenihi

Alabi

et al. 2022

Journal of Food Biochemistry

View full text Add to dashboard Cite

Reactive oxygen species (ROS) exhibit a double-edged sword in cancer-hence their modulation has been an attractive strategy in cancer prevention and therapy. The abundance of scientific information on the pro-oxidant effects of apigenin in cancer cells suggests the crucial role of ROS in its mechanisms of action. Although apigenin is known to enhance the cellular ROS levels to cytotoxic degrees in cancer cells in vitro, it remains to be determined if these pro-oxidant effects prevail or are relevant in experimental tumor models and clinical trials. Here, we critically examine the prooxidant and antioxidant effects of apigenin in cancer to provide insightful perspectives on the association between its ROS-modulating action and anticancer potential.We also discussed these effects in a cell/tissue type-specific context to highlight the factors influencing the switch between antioxidant and pro-oxidant effects. Finally, we raised some questions that need addressing for the potential translation of these studies into clinical applications. Further research into this duality in oxidant actions of apigenin, especially in vivo, may enable better exploitation of its anticancer potential.Practical application: Apigenin is a naturally occurring compound found in chamomile flowers, parsley, celery, peppermint, and citrus fruits. Many human trials of dietary interventions with apigenin-containing herbs and flavonoid mixture on oxidative stress markers, for instance, point to their antioxidant effects and health benefits in many diseases. Preclinical studies suggest that apigenin alone or its combination with chemotherapeutics has a strong anti-neoplastic effect and can induce ROS-mediated cytotoxicity at concentrations in the micromolar (μM) range, which may not be feasible with dietary interventions. Enhancing the in vivo pharmacokinetic properties of apigenin may be indispensable for its potential cancer-specific pro-oxidant therapy and may provide relevant information for clinical studies of apigenin either as a single agent or an adjuvant to chemotherapeutics.

show abstract

Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota

Cited by 21 publications

References 40 publications

Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention

Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention

The Effects and Mechanisms of Flavonoids on Cancer Prevention and Therapy: Focus on Gut Microbiota

Reactive oxygen species: Key players in the anticancer effects of apigenin?

Contact Info

Product

Resources

About