Drug resistance remains a major clinical obstacle to successful treatment in breast cancer patients, and the evidence of microRNAs involvement in cancer drug resistance has been emerging recently. However, the role of microRNA-200c (miR-200c) in modulating chemoresistance of breast cancer remains largely unexplored. Here, we investigated the miR-200c expression in tumor specimens obtained from thirty-nine breast cancer patients who received neoadjuvent chemotherapy by quantitative real-time PCR. Down-regulated miR-200c was observed in non-responders as compared to responders. In addition, miR-200c expression was observed to be down-regulated over 800-fold in human breast cancer cells resistant to doxorubicin MCF-7/ADR as compared to the parental MCF-7 cells. Up-regulation of miR-200c with transfection of miR-200c mimics in breast cancer cells could enhance the chemosensitivity to epirubicin and reduce expression of multidrug resistance 1 mRNA and P-glycoprotein. Moreover, our study demonstrated that restoration of miR-200c in MCF-7/ADR cells could increase intracellular doxorubicin accumulation determined by flow cytometry. Taken together, our findings suggest that miR-200c may act as a promising therapeutic target for improvement of responsiveness to chemotherapy in breast cancer.

Both activated carbon nanoparticles suspension in vivo and methylene blue in vitro can be used as tracers to increase the detected number of lymph nodes in colorectal cancer.

The recent intensification of trade winds over the tropical Pacific is the strongest ever observed in the past hundred years. This strengthening trend is of great interest in recent research, but the causes are still unclear. Using two relatively long‐term surface wind data sets, the present research shows that there is an overall strengthening trend of the trades in the western equatorial Pacific and an overall weakening trend in the eastern equatorial Pacific. This long‐term trend pattern can be primarily attributed to the cold tongue mode (CTM) rather than to the impact of El Niño–Southern Oscillation (ENSO), El Niño Modoki, or Interdecadal Pacific Oscillation (IPO). The CTM, the second empirical orthogonal function mode of the sea surface temperature anomalies (SSTA) in the tropical Pacific, represents a strong long‐term trend of tropical Pacific background state under global warming. According to the Gill‐Matsuno theory, the easterly winds over the western equatorial Pacific are induced by the equatorial Pacific cooling and warming SSTA associated with the CTM, while the westerly winds over the eastern equatorial Pacific is primarily due to the eastern equatorial Pacific cooling SSTA associated with the CTM. Ultimately, an alternative explanation of past and future changes of the trades is expected to lead to improved understanding of the global climatic impacts of the enhanced trades in tropical Pacific under global warming.

SPNs are rare neoplasms with malignant potential but excellent prognosis. Adequate surgical resection, including laparoscopic surgery, may therefore be performed safely and is associated with a long-term survival, even in invasive cases.

Radiofrequency ablation (RFA) has been widely accepted as an alternative treatment for unresectable primary and metastatic hepatic tumors, with satisfactory rates of local response and significant improvements in rates of overall survival. Numerous large series studies have shown that RFA is safe and effective, with a low mortality rate and a low major complication rate. Major complications, including diaphragmatic perforation and hernia, have rarely been previously reported. The current case report presents a case of diaphragmatic hernia with perforation of the incarcerated colon in the thoracic cavity 12 months following hepatic RFA, and reviews nine previously reported cases of diaphragmatic hernia. Comprehensive analysis of the nine cases demonstrated possibilities leading to diaphragmatic hernia following diaphragmatic thermal injury as a consequence of hepatic RFA. Clinicians and radiologists must consider diaphragmatic thermal damage following hepatic RFA for liver tumors adjacent to the diaphragm, particularly for patients with symptoms of ileus, dyspnea, chest pain, pleural effusion and right shoulder pain.