Tauopathy is a complex disorder associated at the junction of several other pathologies. Intrinsically disordered tau protein remains therapeutically challenging due to its undruggable nature and is a possible reason for monumental failure of several tau‐based therapies. Herein, nanogold remodeled tau is reported as a pseudo‐nanochaperon and shows therapeutic benefit by passive targeting in transgenic tau P301L mutant mice. Treatment with nanogold polyethylene glycol (Au‐PEG) conjugate moderately improves the learning ability of the tau P301L mice that corroborates with diminished phosphorylated tau burden. Circulating total tau level that acts in a prion fashion is significantly reduced upon Au‐PEG treatment. Similarly, a high level of tau is found in macaque monkey serum and Au‐PEG inhibits amyloidosis of Alzheimer's patients and primate's serum samples ex vivo. Addtionally, brain MRI of an old aged macaque monkey shows the decrease of grey matter, which correlates with mutual loss of grey matter upon progressive dementia as reported. Au‐PEG tunes tau and other circulating pro‐dementia factors that are present in human AD serum, by remodeling the protein and repairing aberrant proteostasis. Alteration of proteotoxic tau function by nanogold as a kinetic stablizer holds translational potential to combat socially challenging dementia.

A series of Ba 2 ZnB 2 O 6 :Eu 3+ phosphors with a red-emitting band centered at 616 nm were prepared by traditional high temperature solid-state reaction methods. The site-preferred occupancy of Eu 3+ in Ba 2 ZnB 2 O 6 and luminescence properties of Ba 2 ZnB 2 O 6 :Eu 3+ were studied combined with X-ray diffraction (XRD), photoluminescence excitation (PLE) spectra and emission (PL) spectra as well as temperature-dependent PL and decay curves. The Rietveld refinements indicate that the Eu 3+ ions prefer to occupy Zn (1) (4a) and Zn (2) (4a) sites simultaneously. The PL intensity is improved with increasing Eu 3+ content and the optimal dopant content is 0.05. The temperature-dependent PL spectra indicate that the emission intensity decreases with the temperature because of the enhancement of the nonradiative transition. The PL emission intensities of Ba 2 ZnB 2 O 6 :0.05Eu 3+ phosphors with Li + , Na + and K + as charge compensators are enhanced significantly, and the phosphor compensated by Li + ions emits the strongest emission. The Commission Internationale de I'Eclairage (CIE) color coordinates of Ba 2 ZnB 2 O 6 :0.05Eu 3+ are very close to the CIE of standard red light.

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Mn(2+)-activated red phosphor α-LiZnBO3:Mn(2+) was synthesized by solid state reaction. ESR spectra prove that the doped ions are Mn(2+). The doped Mn(2+) ion is inclined to occupy Zn(2+) site, which is a tetrahedral coordination. The diffuse reflection spectra indicate that α-LiZnBO3:Mn(2+) has strong absorption in the range of 400-450 nm. Excited at 431 nm, an abnormal red emission band in the wavelength of 550-800 nm is observed, which is because of the strong crystal field induced by the distorted tetrahedral. The emission bands are centered at 647 nm, regardless of the excitation wavelength and Mn(2+) doping concentration. The temperature-dependent PL results reveal that α-LiZnBO3:Mn(2+) is thermally stable but the emission peak moves to shorter wavelength as temperature increases because of the decrease of the crystal field.

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