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Aiming at the high temperature and high salinity of Keshen 8 gas reservoir, the selective water plugging agent system with high temperature resistance, salt resistance and water permeability was studied. The effect of the plugging system components on the performance of plugging agent was investigated by single factor experiment, and the best formula was determined. The compressive strength of the material was stable at about 4.6 MPa, and the plugging agent had good temperature and salt resistance. Through the physical simulation experiment of fracture core flow, the plugging effect of different plugging agent injection volume on plugging agent is discussed. When the injection volume is 0.3 PV, the liquid phase plugging rate is 86.69 %, and the gas phase plugging rate is 26.18 %, which has good water resistance and gas permeability.