Objective: Hyoid bone metastasis from lung adenocarcinoma is exceedingly rare. This study aims to provide an experience to clinicians in the differential diagnosis of hyoid tumors and discusses its possible source. Methods and Results: We report a 68-year-old male patient having hyoid bone metastasis from lung adenocarcinoma. The initial symptom of the hyoid bone metastasis was neck pain exacerbated by swallowing. The hyoid bone mass was resected based on comprehensive analysis including whole-body bone imaging and pathologic analysis of the hyoid bone mass. The adenocarcinoma of hyoid was identified as a metastatic lesion of lung adenocarcinoma. The patient recovered well and the anterior cervical pain was significantly alleviated after surgery and the patient underwent corresponding chemotherapy. Conclusion: In patients with hyoid metastasis of lung adenocarcinoma, surgical resection may reduce the pain in anterior cervical after full consideration of physical condition.

Background. We aimed to establish a model to predict the prognosis of patients with thyroid cancer based on differentially expressed hypoxia-related genes.Methods. By comparing the genes in TCGA database and hypoxiaDB database, we obtained differentially expressed genes (DEGs) related to hypoxia in thyroid cancer. Gene function enrichment analysis was performed, and a protein-protein interaction network was constructed using the STRING database. Univariate Cox regression were used to screen hypoxia-related genes with prognostic value. Subsequently, multivariate Cox analysis was used to determine prognostic markers based on thyroid cancer, a prognosis model based on these genes was established. The Kaplan-Meier analysis, Receiver operating characteristic (ROC) analysis and The Harrell’s concordance indexes in the training set and the validation set were used to evaluate the performance of the model. Finally, we conducted univariate analyses of the prognostic value of clinical data (including risk scores) of thyroid cancer patients.Results. 326 hypoxia-related thyroid cancer genes were found. Functional enrichment analysis demonstrated they were mainly involved in regulating biological functions. 23 genes have been proved to be associated with the prognosis of thyroid cancer with univariate Cox regression, among them, 11 marker genes were used to construct a new prognosis model by multivariate Cox analysis. Accordingly, the system of risk scores was constructed, patients with high-risk scores (P <0.005) had shorter overall survival than those with low-risk scores. The ROC curve indicated good performance of the eleven-gene signature at predicting overall survival. The Harrell’s concordance indexes in the internally validated for the 11-gene prognostic signature was 0.881. Moreover, univariate analysis showed that the risk score and age were significantly associated with patient overall survival. The model we created was significantly associated with patient overall survival.Conclusions. The model we established had excellent performance in the prognosis of thyroid cancer.

Objective: To compare the clinical application effects of peripherally inserted central catheter (PICC) and deep venous catheters placed through the lower limbs in adults, and to explore the advantages of ultrasound-guided PICC through the lower limbs in adults. Methods: A retrospective study was conducted on 27 bedridden patients with advanced malignant tumor between February 2017 and February 2019. The success rate of one-time catheterization, the length of catheterization puncture time, the number of catheterizations, and the occurrence of catheter-related complications of the two methods were compared. Results: Results of the study showed that ultrasound-guided PICC through the lower limbs has a higher success rate than deep venous catheterization. The average length of puncture time in adults with PICC through the lower limbs under ultrasound guidance was shorter than that in the femoral vein group. There was no significant difference in the incidence of catheter-related complications between the two groups. Conclusion: The indications for PICC through the lower limbs in adults include patients with advanced malignant tumor after bilateral breast cancer lymphadenectomy or superior vena cava obstruction syndrome, and mainly bedridden patients. This technique has certain advantages over deep venous catheterization and is an effective choice for venous access.