A skin adhesive patch is the most fundamental and widely used medical device for diverse health-care purposes. Conventional skin adhesive patches have been mainly utilized for routine medical purposes such as wound management, fixation of medical devices, and simple drug release. In contrast to traditional skin adhesive patches, recently developed patches incorporate multiple key functions of bulky medical devices into a thin, flexible patch based on emerging nanomaterials and flexible electronic technologies. Consequently, the meaning of the term "skin adhesive patch" becomes broader and smarter compared to the traditional term. This review summarizes recent efforts undertaken in the development of multifunctional advanced skin adhesive patches, and briefly describes future directions and challenges toward the next generation of smart skin adhesive patches for ubiquitous personalized health care.

Photonic skins enable a direct and intuitive visualization of various physical and mechanical stimuli with eye-readable colorations by intimately laminating to target substrates. Their development is still at infancy compared to that of electronic skins. Here, an ultra-adaptable, large-area (10 × 10 cm 2 ), multipixel (14 × 14) photonic skin based on a naturally abundant and sustainable biopolymer of a shape-memory, responsive multiphase cellulose derivative is presented. The wearable, multipixel photonic skin mainly consists of a photonic sensor made of mesophase cholesteric hydroxypropyl cellulose and an ultraadaptable adhesive layer made of amorphous hydroxypropyl cellulose. It is demonstrated that with multilayered flexible architectures, the multiphase cellulose derivative-based integrated photonic skin can not only strongly couple to a wide range of biological and engineered surfaces, with a maximum of ≈180 times higher adhesion strengths compared to those of the polydimethylsiloxane adhesive, but also directly convert spatiotemporal stimuli into visible color alterations in the large-area, multipixel array. These colorations can be simply converted into 3D strain mapping data with digital camera imaging.

This study presents a wet-responsive and biocompatible smart hydrogel adhesive that exhibits switchable and controllable adhesions on demand for the simple and efficient transfer printing of nanomembranes. The prepared hydrogel adhesives show adhesion strength as high as ≈191 kPa with the aid of nano-or microstructure arrays on the surface in the dry state. When in contact with water, the nano/microscopic and macroscopic shape reconfigurations of the hydrogel adhesive occur, which turns off the adhesion (≈0.30 kPa) with an extremely high adhesion switching ratio (>640). The superior adhesion behaviors of the hydrogels are maintained over repeating cycles of hydration and dehydration, indicating their ability to be used repeatedly. The adhesives are made of a biocompatible hydrogel and their adhesion on/off can be controlled with water, making the adhesives compatible with various materials and surfaces, including biological substrates. Based on these smart adhesion capabilities, diverse metallic and semiconducting nanomembranes can be transferred from donor substrates to either rigid or flexible surfaces including biological tissues in a reproducible and robust fashion. Transfer printing of a nanoscale crack sensor onto a bovine eye further demonstrates the potential of the reconfigurable hydrogel adhesive for use as a stimuliresponsive, smart, and versatile functional adhesive for nanotransfer printing.

A flexible microneedle patch that can transdermally deliver liquid-phase therapeutics would enable direct use of existing, approved drugs and vaccines, which are mostly in liquid form, without the need for additional drug solidification, efficacy verification, and subsequent approval. Specialized dissolving or coated microneedle patches that deliver reformulated, solidified therapeutics have made considerable advances; however, microneedles that can deliver liquid drugs and vaccines still remain elusive because of technical limitations. Here, we present a snake fang–inspired microneedle patch that can administer existing liquid formulations to patients in an ultrafast manner (<15 s). Rear-fanged snakes have an intriguing molar with a groove on the surface, which enables rapid and efficient infusion of venom or saliva into prey. Liquid delivery is based on surface tension and capillary action. The microneedle patch uses multiple open groove architectures that emulate the grooved fangs of rear-fanged snakes: Similar to snake fangs, the microneedles can rapidly and efficiently deliver diverse liquid-phase drugs and vaccines in seconds under capillary action with only gentle thumb pressure, without requiring a complex pumping system. Hydrodynamic simulations show that the snake fang–inspired open groove architectures enable rapid capillary force–driven delivery of liquid formulations with varied surface tensions and viscosities. We demonstrate that administration of ovalbumin and influenza virus with the snake fang–inspired microneedle patch induces robust antibody production and protective immune response in guinea pigs and mice.

Stable and reversible adhesion to wet surfaces is challenging owing to water molecules at the contact interface. In this study, we develop a hydrogel-based wet adhesive, which can exhibit strong and reversible adhesion to wet and underwater surfaces as well as to dry surfaces. The remarkable wet adhesion of the hydrogel adhesive is realized based on a synergetic integration of bioinspired microarchitectures and water-friendly and water-absorbing properties of the polymeric hydrogel. Under dry conditions, the microstructured hydrogel adhesive exhibits strong van der Waals interaction-based adhesion, while under underwater conditions, it can maximize capillary adhesion. Consequently, the hydrogel adhesive exhibits remarkable adhesion strengths for dry, moist, and submerged substrates. Maximum normal and shear adhesion strengths of 423 and 384, 492 and 340, and 253 and 21 kPa are achieved with the hydrogel adhesive for dry, moist, and submerged substrates, respectively. Our results demonstrate that strong wet and underwater adhesion can be achieved only with the hydrogel-based adhesive with simple microscale architecture.