Background Data: Glucocorticoid-induced osteoporosis is a well-known significant health problem worldwide that causes morbidity and mortality. Glucocorticoid-induced vertebral compression fracture is one of the most common types of osteoporotic fractures associated with significant morbidities such as severe agonizing pain, limited mobility, and spinal deformity. Percutaneous vertebroplasty (PV) can be performed in the treatment of refractory back pain in these cases of osteoporotic vertebral fractures (OVFs) without significant complication when conservative treatment fails. Purpose: To evaluate the clinical and radiographic outcomes of thoracolumbar OVFs treated with PV in adult osteoporotic patients with long-term corticosteroid therapy. Study Design: Retrospective clinical case series. Patients and Methods: Twenty-eight patients with painful steroid-induced OVFs underwent vertebroplasty in 61 vertebral levels. Inclusion and exclusion criteria were applied. Preoperatively, all patients were subjected to intensive diagnostic workups, including history taking and clinical and radiological examinations, such as CT scan and MRI. The procedure was guided by C-arm and considered complete when the unfilled area was less than 25% of the vertebral body height in the lateral radiograph. Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) were used to assess pre-and postoperative back pain and functional status of our patients. Results: Seventeen patients (60.71%) were males and eleven patients (39.28%) were females. The mean age was 57 ± 5.04 (range, 49-68) years. The mean follow-up of the patients was 38.4 2± 11.16 (range, 24-60) months. Overall, 61 levels were reported including 10 patients (39%) with a single level and 18 patients (61%) with two levels or more as follows: two levels in eight patients, three levels in six patients, four levels in three patients, and one patient with five levels. The most common affected region was the thoracolumbar junction (T11, T12, and L1) in 38.69%.