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In this study, we synthesized some new derivatives of N‐(4‐amino‐5‐cyano‐6‐(trichloromethyl)pyridin‐2‐yl)alkyl sulfonamides in the presence of a copper catalyst. A one‐pot reaction system was used, and four components participated in the process. These four components were sulfonyl azides, terminal alkynes, malononitrile, and trichloroacetonitrile. The reaction rate was increased by the use of copper (I) iodide as the catalyst and tetrahydrofuran was used as the solvent. We achieved the final compounds in moderate to good yields. Moreover, we converted “NH2” side group to N‐aryl by the use of various aryl halide analogs in acetonitrile as the solvent, under mild reaction and at the room temperature.

A novel series of 2-(trichloromethyl)-1H-benzo[d]imidazole analogs were synthesized via an ultrasonic-assisted, one-pot, copper-catalyzed three-component reaction of the aminetrichloroacetonitrile adduct and 1, 2-dihalo benzene at room temperature. Affordable starting materials, simple work-up method, short reaction time process and relatively high yields were the advantages of this modified version of Ullmann reaction.