A series of new indeno[1,2‐b]quinoxaline compounds containing pyrrolopyrimidine skeleton have been synthesized in excellent yields using an improved and efficient synthetic methodology under ultrasonic irradiation in the absence of any added catalyst. The reactions were carried out under both thermal and ultrasonic irradiation condition. In general, obvious improvement in reaction time and milder conditions were observed when reactions were carried out under sonication compared with conventional silent conditions.

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The pyrimidines fused with pyrrole ring, pyrrolopyrimidines, showed broad applicability in medicinal chemistry. Herein, we synthesized the new derivatives (8 examples) of pyrrolo[1,2-a] pyrimidine containing 1,3-indandione skeleton by the use of triethylammonium thiolates, methyl iodide, and ketene aminals via a one-pot three-component reaction. Scheme 1. Synthesis of pyrrolo[1,2-a]pyrimidine containing 1,3-indandione skeleton.