Purpose-To evaluate factors associated with favorable outcomes after vitrectomy for diabetic macular edema (DME).Methods-Data were collected prospectively on 241 eyes undergoing vitrectomy for DME. Multivariate models were used to evaluate associations of 20 preoperative and intraoperative factors with 6-month outcomes of visual acuity and retinal thickness.Results-Median central subfield thickness decreased from 412 μm to 278 μm at 6 months, but median visual acuity remained unchanged (20/80, Snellen equivalent). Greater visual acuity improvement occurred in eyes with worse baseline acuity (P<0.001) and in eyes in which an epiretinal membrane was removed (P = 0.006). Greater reduction in central subfield thickness occurred with worse baseline visual acuity (P<0.001), greater preoperative retinal thickness (P = 0.001), removal of internal limiting membrane (P = 0.003), and with optical coherence tomography evidence of vitreoretinal abnormalities (P = 0.006). No associations with clinician's preoperative assessments of the posterior vitreous were identified.Conclusion-These results suggest that removal of epiretinal membranes may favorably affect visual outcome after vitrectomy. Pre-operative presence of vitreoretinal abnormalities appeared to be associated with somewhat greater reductions in retinal thickness but not with visual acuity outcome. These results may be useful for future studies evaluating vitrectomy for DME.Summary Statement-In 241 eyes undergoing vitrectomy for diabetic macular edema, greater improvement in retinal thickening was independently associated with both greater thickening and worse visual acuity preoperatively, but greater improvement in visual acuity only with worse preoperative visual acuity, in both cases likely reflecting, at least in part, ceiling effects.

No abstract

No abstract

A single subthreshold 810-nanometer laser treatment to eyes of participants with bilateral high risk drusen is not an effective prophylactic strategy against choroidal neovascularization.

Although the authors were on the "learning curve" of experience during this series, REVS appears to promote visual recovery far in excess of what would be expected to occur spontaneously, and IVTA injection greatly improved outcomes. We believe that mastery of REVS techniques and the inclusion of IVTA injection may lead to better visual results and lower complication rates.