Viruses continued to emerge and bring challenges to the global public health system with emerging viruses with respiratory contagion. Previous studies have shown that the increased incidence of certain viral respiratory infections, including influenza and coronavirus, is associated with low levels of Vitamin D, zinc and iron. Elements such as iron, zinc and Vitamin D influence adaptive immunity by inhibiting the proliferation of B cells with differentiation and secretion of immunoglobulins that will supply the proliferation of T cells and this will result in a more pro-inflammatory response change.

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In recent years, new viruses have emerged and caused pandemics in several countries, making it a global health problem through respiratory infection. This study aims to demonstrate through an analysis of evidence, that vitamin D supplementation in cases of hypovitaminosis D in risk groups induces an increase changes in the immune system due to worsening and, thus, the body becomes conducive to development viral diseases like COVID-19. Therefore, methodological techniques were used in meta-analysis and systematic reviews parallel to the FINER strategy in the selection of the included studies to be used in the construction of this critical analysis. In this study, 05 articles were selected for inclusion in this critical analysis. Vitamin D plays an immune protective role in the body, decreasing the risk of complications in COVID-19. The decrease in immune cells and cytokines can be used as a biomarker in the process of worsening COVID-19.

Objectives: Autoimmune diseases can cause laryngeal involvement with a highly variable course ranging from asymptomatic to severe states. Just few cases have been described since 1959, when the first laryngeal manifestation of systemic lupus erithematosus (SLE) was published. The aim of this article is to identify and to describe laryngeal manifestations of autoimmune diseases. Methods: Transversal study with patients presenting SLE, scleroderma, or undifferentiated connective tissue syndrom (UCTS) at Sao Paulo HospitalUniversidade Federal de Sao Paulo/Escola Paulista de MedicinaSao Paulo, Brazil. These patients underwent otorhinolaryngologic evalution with laryngeal videostroboscopic image. Results: Twenty-six patients underwent laryngeal videostroboscopic evaluation. One patient could not support the exam. Eleven of 12 (91.6%) patients with SLE presented edema of interarytenoid tissue. Bamboo nodes, that are yellow transverse submucosal vocal fold deposit lesions, were seen in 03 (25%) patients with SLE. One (8.33%) patient had unilateral sulcus vocalis. All 11 patients with scleroderma presented reflux laryngopharyngitis. Two (18.1%) patients presented dilatation of vocal fold blood vessels and another 2 patients presented vocal fold nodule. Among 3 patients with UCTS, in 2 (66.7%) were seen bamboo nodes and reflux laryngopharyngitis. Conclusion: Laryngeal manifestations due to autoimmune diseases were seen in 07 (26.9%) of 26 patients. Bamboo nodes were seen in 5 (19.2%) patients. Almost all patients presented reflux laryngopharyngitis.

Cancer treatment has been constantly improved to cause the least possible harm to the patient. New therapies are being researched, many of them having as object of scientific-academic and pharmacological research the use of cyanogenic plants and their antitumor chemical compounds that can bring benefits to human health, having the potential to be associated with the magnetic Field and thus achieve a better benefit and with reduced adverse effects in cancer treatment. This study aimed to review the effect of cyanogenic substances and magnetic Field on tumor evolution in the literature. The integrative review of the literature was carried out in the databases EMBASE, PUBMED, LILACS, VHL, SCOPUS and MEDLINE. A final sample of 14 scientific articles, published from 2011 to 2020, was obtained, highlighting that cyanogenic substances and the magnetic Field can help reduce tumors. The most common studies were on the magnetic Field, and the studies were carried out mainly in vitro, with a frequency of 50 Hz that stood out from the others. Among the cyanogenic substances, the most prevalent was tonsillin, with the most used dosage of 10mg / ml. It was possible to conclude that both the magnetic Field and cyanogenic substances can reduce tumors.