In this study, the interactions of different groups substituted isoeuxanthone derivatives with calf thymus DNA (ct DNA) were investigated by spectrophotometric methods and viscosity measurements. Results indicated that the xanthone derivatives could intercalate into the DNA base pairs by the plane of xanthone ring and the various substituents may influence the binding affinity with DNA according to the calculated quenching constant values. Furthermore, two tumor cell lines including the human cervical cancer cell line (HeLa) and human hepatocellular liver carcinoma cell line (HepG2) were used to evaluate the cytotoxic activities of xanthone derivatives by acid phosphatase assay. Analyses showed that the oxiranylmethoxy substituted xanthone exhibited more effective cytotoxic activity against the cancer cells than the other substituted xanthones. The effects on the inhibition of tumor cells in vitro agreed with the studies of DNA-binding.
An experimental research was performed on the compressive strength and splitting tensile strength for HSC with various polypropylene(PP) fibers after exposure to temperatures 300°C, 500°C, 700°C, 900°C. Cubes of 150mm×150mm were designed and fabricated with C60, blended with silica fume and slag, mixed with PP fibers, respectively. These specimens were naturally cooled to room temperature after being heated in an electric furnace. No explosive spalling was observed during the fire test on all HSC with PP fibers. From the results of nine types of concretes, both the compressive strength and splitting tensile strength of HSC with PP fibers decreased with the increase of temperature. Through a series of measurement, the relationships between the mechanical properties and the various PP fibers in HSC were analyzed, including the dosage and length of PP fiber. Based on the comparison in the experimental results, the proposed optimum of PP fiber in HSC was 1.5kg/m3 under the test condition. In addition, PP fiber with the length of 8mm could be more applicable to use.
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