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This work proposed ratiometric fluorescence capillary sensing systemintegrated molecular imprinting with highly sensitive and selective detection for two biological indicators of Parkinson's disease (homovanillic acid (HVA) and Al 3+ ). In this research, the silicon carbon quantum dot and the near-infrared CdTe quantum dot as luminescence sources were doped to an imprinted layer, which was attached to the inner surface wall of an amino-functionalized capillary. The fluorescence emissions of the ratiometric fluorescence capillary-imprinted sensor at 434 and 707 nm were quenched by HVA, and only the fluorescence emission at 434 nm was quenched by Al 3+ . Ratiometric fluorescence capillary sensing system-integrated molecular imprinting was used to detect simultaneously HVA and Al 3+ with linearity over 1.0 × 10 −9 −2.5 × 10 −7 and 1.0 × 10 −9 −1.1 × 10 −7 M, respectively. The sensor showcased detection limitations of 8.7 × 10 −10 and 9.8 × 10 −10 M, indicating that the ratiometric fluorescence capillary sensing system-integrated molecular imprinting had great potential application for detecting HVA and Al 3+ in serum and urine samples. The ratiometric fluorescence capillary sensing system-integrated molecular imprinting achieved highly sensitive and selective detection of HVA and Al 3+ with a microvolume test dosage of 18 μL, which provided a new way for early diagnosis and disease monitoring of Parkinson's disease.

Taro stalks (TS) were modified by diethylenetriamine (DETA) to obtain the modified taro stalks adsorbents (recorded as MTSA). This kind of raw material is unprecedented and the method of modification is relatively simple. The physicochemical properties of MTSA were characterized by scanning electron microscope (SEM), FTIR, and zeta potential analyzer. The capacity of MTSA for adsorbing heavy metals under different influencing factors was tested by UV-visible spectrophotometer. The results indicated that the gaps between the microspheres of MTSA are more, which are conducive to adsorption. The MTSA might have increased the amino-functional groups which are beneficial for adsorption, resulting in an increase in the adsorption capacity of copper and nickel ions (35.71 and 31.06 mg/g) of about 5-7 times compared to bare taro stalks (5.27 mg/g and 6.08 mg/g). High Cu uptake on MTSA was observed over the pH range of 5.5-7.0, while for Ni the range was 7.0-8.5, and the optimum dosage of adsorbent were both about 0.80 g for Cu and Ni. The adsorption kinetics of Cu and Ni on MTSA could be interpreted with a pseudo-second order and the equilibrium data were best described by the Langmuir isotherm model. Graphical abstract ᅟ.

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