Aim Patients with gynaecological cancer often experience high levels of uncertainty in illness during chemotherapy and report unmet supportive care needs. Mobile applications (apps) are increasing being used as an easily accessible alternative to support these patients, but a lack of rigorous trials have been conducted to explore their effectiveness. Based on Mishel's uncertainty in illness theory, the Mobile Gynaecological Cancer Support (MGCS) program is an app‐based program that includes four modules: 1) weekly topics, 2) emotional care, 3) discussion centre and 4) health consultation. The aim of this study is to assess the effectiveness of MGCS for Chinese patients with gynaecological cancer receiving chemotherapy in respect of reducing uncertainty in illness and symptom distress and improving quality of life and social support. Design A multi‐centre randomized controlled trial will be used. Methods One hundred and sixty‐eight patients with gynaecological cancer commencing chemotherapy will be recruited from three university affiliated hospitals and assigned to the control or intervention group with block randomization. The control group will only receive routine care. The intervention group will access the MGCS program for 24 weeks and receive routine care. Health outcomes will be evaluated at baseline, 12 weeks, and 24 weeks. Repeated measures multivariate analysis of covariance (intention‐to‐treat) will be used to assess the effectiveness of MGCS. Discussion This is the first trial to explore the effectiveness of an app‐based program for patients with gynaecological cancer using a robust and rigorous study design in China. If effective, this trial will provide evidence for an app‐based program to support these patients. Impact The knowledge gained can be applied to develop other culturally appropriate app‐based programs for cancer groups worldwide, and provide evidence for health policymakers to allocate more resources and train staff for e‐health. Trial Registration ChiCTR2000033678 (Chinese Clinical Trial Registry Registered 08 June, 2020).

• Online interventions have been increasingly used to promote health outcomes for patients with gynecological cancer. • Online interventions were demonstrated to improve quality of life and body images for patients with gynecological cancer. • Online interventions were reported to have inconclusive effects on symptom distress and social support. • Online interventions were reported to have inconsistent effects on psychological well-being and sexual well-being. • Studies with more rigorous designs and sufficient sample sizes are needed for further exploration.

Aim To explore the mediating role of fear and resilience on the relationship between clinical nurses' reporting of skin lesions and their anxiety and depression during the coronavirus disease 2019 (COVID‐19) pandemic. Background Prolonged personal protective equipment wearing may cause severe skin lesions among clinical nurses. The possible relationship between clinical nurses' reporting of skin lesions and their anxiety and depression remains unknown. Moreover, little is known about what factors could mediate such a relationship. Methods This is a cross‐sectional online survey. CHERRIES was used to report results. Results Of 2014 participants, 94.8% ( n = 1910) reported skin lesions. Skin lesions were positively related to anxiety ( p < .001, β = .228, SE = .099) and depression ( p < .001, β = .187, SE = .093). Fear activated while resilience buffered the relationship between clinical nurses' reporting of skin lesions and anxiety and between skin lesions and depression. Conclusion Reduced fear and enhanced resilience level were related to decreased levels of anxiety and depression among clinical nurses. Implications for nursing management Nurse managers should evaluate the occurrence and severity of clinical nurses' skin lesions, arrange reasonable working duration to relieve skin lesions, provide appropriate psychological support to reduce clinical nurses' fear and implement various strategies to enhance their resilience, thereby decreasing their anxiety and depression. Clinical trial registration number: ChiCTR2000030290

(Abstracted from Gynecol Oncol 2020;158:143–152) Cancer diagnosis and subsequent treatment can have a significant impact on the quality of life of patients with gynecological cancer. Beyond physical symptoms including nausea, fatigue, pain, and changes in urination and bowel movements, there are often more nuanced and psychological effects including depression, decreases in social support, and adversely impacted sexual well-being and body image.