Co/Mn-MOFs-1-1-150, a two-dimensional sheet-like bimetallic Co/Mn-based MOF with peroxidase-like activity, efficiently accelerates the oxidation of TMB in the presence H2O2.

Detecting hydrogen peroxide (H 2 O 2 ) is obviously indispensable on account of its low toxicity and wide application, and it is still a challenge for developing highly sensitive and selective electrochemiluminescence (ECL) sensors based on the noble metal-free electrode. Hence, we designed an accurate ECL sensor for detecting trace H 2 O 2 based on N-doped porous carbon containing Fe (Fe/N-C) nanocomposites, which were successfully synthesized by pyrolysis of NH 2 -MIL-101(Fe) metal-organic framework (MOF). Fe/N-C nanocomposite significantly improved the electron transfer process and enhanced the catalytic activity of ECL sensor for trace H 2 O 2 detection. Fe/N-C nanocomposite significantly contributed in the conversion of H 2 O 2 to superoxide radical, followed by the oxidation of luminal which enhanced the electrochemical luminescence signal. Predictably, the ECL sensing strategy at Fe/N-C nanocomposite electrode showed a satisfying linear range from 1 nM to 300 nM for H 2 O 2 detection with limit of detection (LOD) as 0.93 nM (signal to noise ratio (S/N) = 3). Also, the ECL sensor was used to detect H 2 O 2 in real water samples and renal epithelial 293T cells, which justified great promise for the practical ECL detection of H 2 O 2 .

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