The high prevalence of cancer in the world makes many researchers look for alternative therapies that can be used to treat cancer. One of them is by using traditional plants, namely Calotropis gigantea R.Br. This is due to alkaloids, glycosides, and tannins in plants that function as anticancer. The purpose of this study was to dig deeper into information related to the phytochemistry and pharmacology effect of Calotropis gigantea as an anticancer therapy and can be used as a reference for the development of traditional medicines. The method used is PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses), with inclusion and exclusion criteria, 11 articles were selected for review. The results showed that Calotropis Gigantea contains Calotropin, Calotroposide A, oxypregnane oligoglycoside compounds, which inhibit cancer cell growth through the mechanism of apoptosis induction and ROS inhibition. From this systematic review, it can be recommended that the plant Calotropis gigantea can be further developed into standardized herbal medicine and phytopharmaceuticals.

The COVID-19 pandemic has brought many changes to society, especially in carrying out daily activities. One of the changes is an increase in self-care and self-medication as an effort to survive during the COVID-19 pandemic. This research was conducted at Madrasah Aliyah (MA) Ruhul Islam Anak Nation Aceh Besar. The school is a boarding school that conducts offline learning activities during the COVID-19 pandemic. The purpose of this study was to find out the description of self-care and self-medication during the COVID-19 pandemic at MA Ruhul Islam Anak Bangsa Aceh Besar. The research method uses descriptive research methods. Data was collected by filling out the questionnaire directly using a sample of 90 respondents. The results showed that the self-care profile showed that respondents who always made efforts to prevent COVID-19 were 21.9% and respondents who always maintained their well-being were 34.4%. In the self-medication profile, data showed that when self-medication, most of the respondents used synthetic drugs (69.5%), most of the respondents received information about self-medication from their parents (57.3%), the purpose of doing self-medication was mostly to increase endurance (45.1%), when doing self-medication, there are respondents who experience side effects, and the most are dizziness (29.1%) and 56.5% of respondents will immediately stop treatment if there are side effects, The most obstacles experienced by respondents in carrying out self-medication was that respondents did not know what medicine to use (40.2%). Based on these results, it can be concluded that it is necessary to increase the prevention of COVID-19 and provide education in conducting self-medication during the COVID-19 pandemic at the Supreme Court of Ruhul Islam Anak Bangsa Aceh Besar.

Increasing sexual reproductive health information and knowledge about Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome in adolescents is one of the targets of the Sustainable Development Goals, 2030. The use of sexual education applications helps educate adolescents that supports the achievement of these targets. This study describes the effect of sexual health education applications on adolescent knowledge and decreases the prevalence of Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome to support the 2030 Sustainable Development Goals. This research is a literature study of articles published in NCBI, Google Scholar, and PubMed. The keywords used in the article search were: sex education, android application, Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome, and reproduction health. Inclusion criteria were articles published in 2016-2020, using English or Indonesian, original article, can be accessed in full text, free of charge and the manuscript content’s were relevant to the study. Review articles and duplicate journals were excluded. In this study, only ten of the 1250 articles met the inclusion criteria. Study shows that sexual education applications can increase adolescents' understanding of reproductive health, good and healthy sexuality, improve sexual attitudes and behavior, and also reduce the prevalence of Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome that supports the 2030 Sustainable Development Goals.