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ObjectivesTo determine the effects of leaf extract of Phoenix dactylifera against the oxidative stress response induced by a wide‐spectrum analgesic paracetamol in rats.MethodsAdult Sprague dawley rats were treated with or without paracetamol (1500mg/kg) and leaf extract of Phoenix dactylifera (300mg/kg). Serum samples were collected to evaluate liver function tests, and hepatic tissue samples were obtained to assess oxidative stress‐related markers and histopathological examination.ResultsPhoenix dactylifera ameliorated paracetamol‐induced elevated serum liver markers such as alkaline phosphatase (ALP), aminotransferases (AST), alanine aminotransferase (ALT) and bilirubin. In addition, Phoenix dactylifera restored paracetamol‐induced reduced levels of liver tissue antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD). Histological analysis demonstrate that Phoenix dactylifera conserved the hepatic tissue against lesions such as inflammation, centrilobular necrosis, and hemorrhages induced by PCM.ConclusionThese findings indicate that Phoenix dactylifera possesses protective effects against paracetamol‐induced liver injury and oxidative stress, and could be used to explore against drug induced deleterious effects in experimental models.Support or Funding InformationNo funding supportThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.