The use of 3D systems in laparoscopic urologic procedures resulted in better image quality and better surgeon performance with lower stress.

Male breast cancer is a rare disease accounting for less than 1% of all breast cancer diagnosis. Male breast cancers occur later in life and are more estrogen receptor-positive compared to female breast cancers. Breast cancer in men is often diagnosed later and survival rates are lower than in female cases. The aim of this retrospective study is to analyze the epidemiological, clinical and therapeutic data of all male breast cancer cases over the span of 11 years to at Methodist Dallas Medical Center between 2010 – 2021. During this time period, there was a total of 1,784 cases of breast cancer diagnosed. There were 8 cases male breast cancers, accounting for 0.45% of all breast cancer cases. The average age of diagnosis was 69.5 years old. The most common type of male breast cancer was invasive ductal carcinoma with 7 cases (87.7%). The remaining 1 case (12.5%) were ductal carcinoma in situ (DCIS). 100% of our male breast cancer cases were estrogen receptor and progesterone receptor positive. No male breast cancer case had Her2/Neu receptor over-expression. Of all male breast cancer cases, 75% had a family history of cancer suggesting that genetic factors play a significant role in the development of breast cancer in men. At time of diagnosis, 4 cases (50 %) were staged at cT4 and the remainder of cases were between cT0 - cT2. 37.5% of all cases had sentinel lymph node involvement at time of diagnosis. From the time period of 2010 – 2014 there were no incidences of male breast cancer; however, from 2015 – 2021 there were 8 total cases. There were 2 cases (25%) of death. Number of Male Breast Cancer Cases by Year Number of Male Breast Cancer Cases by Year Number of male breast cancer cases diagnosed by year at Methodist Dallas Medical Center Epidemiological and Clinical Data of Male Breast Cancer Cases Citation Format: Huy Nong, Vasu Moparty, Atisha Manhas. A Case Series of Male Breast Cancer Patients at Methodist Dallas Medical Center [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P4-03-44.

INTRODUCTION: Nocardia is a unique member of the order, Actinomycetales. It is a gram-positive, aerobic bacteria that is characterized by its filamentous branching that stains acid-fast. It can be found in soil and decaying vegetation, with inhalation of airborne particles being the most common mode of inoculation. Considered to be a rare, opportunistic infection, the incidence rate is approximately 500-1000 cases in the US per year (1). Although it typically leads to cutaneous disease, Nocardia has the ability to disseminate as widespread disease leading to pulmonary and CNS involvement.CASE PRESENTATION: An 81 year old African-American female with a past medical history of non-Hodgkin Lymphoma treated with radiation in 1999, hypertension, diabetes, hypothyroidism, chronic kidney disease, and heart failure with preserved ejection fraction. She presented with worsening dyspnea, orthopnea, and lower extremity swelling and was admitted for heart failure exacerbation. She was found to have multiple, painful skin abscesses. On presentation, she was septic: febrile and tachycardic with profound leukocytosis. Radiographic imaging revealed multiple, large, cystic fluid collections in the neck, bilateral arms, and left leg along with right, hilar lymphadenopathy and apical cavitary lesion in the right lung. There was a large, anterior chest wall mass communicating with the left arm lesion. IR guided biopsy ruled-out malignancy. General surgery performed I&D's of the peripheral lesions whereas Cardiothoracic Surgery performed I&D of the chest wall mass. Aerobic cultures grew gram-positive, branching bacilli that later speciated to Nocardia pneumoniae. DISCUSSION:The patient was diagnosed with Disseminated Nocardiosis with lymphocutaneous and pulmonary involvement. Our work-up was negative for CNS or bone disease. The exact etiology was unclear. She did not endorse direct trauma/inoculation at lesion sites and denied any unusual exposure to soil, decaying vegetation, or aquatic environments. Despite Nocardia's prevalence in immunocompromised hosts, our patient was determined to be immunocompetent. Fortunately, there was no evidence of recurrence of malignancy and she was HIV negative. Her treatment regimen consisted of a dual agent induction therapy for 6 weeks that was followed by a 6 month maintenance period with a single agent. However, Nocardia has a propensity to recur or progress despite appropriate antibiotic therapy and source control.CONCLUSIONS: Nocardiosis has been described as an emerging infectious disease given the higher number of HIV and transplant patients. Notably, Nocardia pneumoniae is not accounted for in 82 percent of US strains isolated between 1995 and 2004 (2). This species was first described in 2004 with either "undetermined clinical significance" versus "pulmonary disease" (3). This would be a novel presentation of disseminated Nocardia pneumoniae in an immunocompetent host.